Structure-activity relationships of histamine H2 receptor ligands

被引：31
|
作者：
Dove, S
Elz, S
Seifert, R
Buschauer, A [1 ]
机构：
[1] Univ Regensburg, Inst Pharm, D-93040 Regensburg, Germany
[2] Univ Kansas, Dept Pharmacol & Toxicol, Lawrence, KS 66045 USA
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 09期
关键词：
H-2 receptor agonists; H-2 receptor antagonists; impromidine analogues; arpromidine; molecular modelling; structure-activity relationships; QSAR; site-directed mutagenesis;
D O I：
10.2174/1389557043403242
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Recent research on histamine H-2 receptor agonists was focused on quantitative structure-activity relationships and receptor models explaining the activity of imidazolylpropylguanidines. Their selectivity for guinea pig vs. human isoforms was investigated using H-2 receptor-G(salpha) fusion proteins and attributed to amino acid differences in transmembrane domains 1 and 7. New antagonists result from approaches to improve pharmacokinetic properties and to design hybrid drugs which additionally have gastroprotective or anti H. pylori activity.
引用
收藏
页码：941 / 954
页数：14
相关论文
共 50 条
  • [21] Structure-activity relationships of ustiloxin analogues
    Joullie, Madeleine M.
    Berritt, Simon
    Hamel, Ernest
    TETRAHEDRON LETTERS, 2011, 52 (17) : 2136 - 2139
  • [22] Structure-activity relationships of herbicidal aryltriazolinones
    Theodoridis, G
    PESTICIDE SCIENCE, 1997, 50 (04): : 283 - 290
  • [23] Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review
    Thirumaran, Sangeetha-Laura
    Lepailleur, Alban
    Rochais, Christophe
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 183
  • [24] Structure-Activity Relationships and Drug Allergy
    Hasdenteufel, Frederic
    Luyasu, Samuel
    Hougardy, Nicolas
    Fisher, Malcolm
    Boisbrun, Michel
    Mertes, Paul-Michel
    Kanny, Gisele
    CURRENT CLINICAL PHARMACOLOGY, 2012, 7 (01): : 15 - 27
  • [25] β3-adrenergic receptor ligands:: insight into structure-activity relationships using Monte-Carlo conformational analysis in water
    De Amici, M
    De Micheli, C
    Kassi, L
    Carrea, G
    Ottolina, G
    Colombo, G
    TETRAHEDRON, 2001, 57 (09) : 1849 - 1855
  • [26] Structure-Activity Relationships in Oxygen Electrocatalysis
    Han, Jingyi
    Sun, Jingru
    Chen, Siyu
    Zhang, Siying
    Qi, Luoluo
    Husile, Anaer
    Guan, Jingqi
    ADVANCED MATERIALS, 2024, 36 (47)
  • [27] Structure-activity relationships of haemolytic saponins
    Voutquenne, L
    Lavaud, C
    Massiot, G
    Le Men-Olivier, L
    PHARMACEUTICAL BIOLOGY, 2002, 40 (04) : 253 - 262
  • [28] Structure-activity relationships for aldehyde categories
    Walker, John D.
    Printup, Heather
    QSAR & COMBINATORIAL SCIENCE, 2008, 27 (04): : 475 - 482
  • [29] Quantitative structure-activity relationships for estrogen receptor binding affinity of phenolic chemicals
    Hu, JY
    Aizawa, T
    WATER RESEARCH, 2003, 37 (06) : 1213 - 1222
  • [30] Synthetic 2-Methoxyestradiol Derivatives: Structure-Activity Relationships
    Peyrat, Jean-Francois
    Brion, Jean-Daniel
    Alami, Mouad
    CURRENT MEDICINAL CHEMISTRY, 2012, 19 (24) : 4142 - 4156
12345