Glycyrrhizin and Glycyrrhetic Acid: Scaffolds to Promising New Pharmacologically Active Compounds

被引：37

作者：

Graebin, Cedric S. ^{[1
,2
]}

Verli, Hugo ^{[1
]}

Guimaraes, Jorge A. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Ctr Biotecnol, BR-91500970 Porto Alegre, RS, Brazil

[2] Univ Fed Rural Rio de Janeiro, Inst Ciencias Exatas, Dept Quim, BR-23890000 Seropedica, RJ, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2010年 / 21卷 / 09期

关键词：

glycyrrhizin; glycyrrhetic acid; glycyrrhetinic acid; licquorice; organic synthesis; pharmacological activity; 18-BETA-GLYCYRRHETINIC ACID; IMMUNOMODULATING ACTIVITY; TRITERPENE DERIVATIVES; ANTIVIRAL ACTIVITY; D-GLUCOSAMINE; INHIBITION; LICORICE; INTERFERON; OLEANANE; LEUKEMIA;

D O I：

10.1590/S0103-50532010000900002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Glycyrrhizinic acid (GL), also known as glycyrrhizin, is a triterpene saponin, a natural product found on the root of Glycyrrhyza glabra L. ("licquorice"), used worldwide as sweetener and in the traditional eastern medicines. This review is focused on a series of new derivatives synthesized using GL and its aglycon, glycyrrhetinic acid (GLA), as starting materials, the pharmacological activities described for those compounds, as well as new activities reported for GL and GLA themselves.

引用

页码：1595 / 1615

页数：21

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