Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity

被引：796

作者：

Amano, Mutsuki ^{[1
]}

Nakayama, Masanori ^{[2
]}

Kaibuchi, Kozo ^{[1
,3
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Cell Pharmacol, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Max Planck Inst Mol Biomed, Dept Tissue Morphogenesis, D-48149 Munster, Germany

[3] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

CYTOSKELETON | 2010年 / 67卷 / 09期

关键词：

Rho; kinase; cytoskeleton; actomyosin; polarity; SMOOTH-MUSCLE-CELLS; MYOSIN LIGHT-CHAIN; BINDING PROTEIN RHO; VENTRAL BODY-WALL; ROCK-I; LIM-KINASE; DEPENDENT PHOSPHORYLATION; MOESIN PHOSPHORYLATION; MEDIATED ACTIVATION; ACTIN CYTOSKELETON;

D O I：

10.1002/cm.20472

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma, and is therefore considered to be a potential therapeutic target This review focuses on the structure, function, and modes of activation and action of Rho-kinase.

引用

页码：545 / 554

页数：10

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