未找到相关数据
Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recoding
被引：17
|作者：
Kwun, Hyun Jin
[1
]
Toptan, Tuna
[1
]
da Silva, Suzane Ramos
[2
]
Atkins, John F.
[3
]
Moore, Patrick S.
[1
]
Chang, Yuan
[1
]
机构：
[1] Univ Pittsburgh, Inst Canc, Canc Virol Program, Pittsburgh, PA 15213 USA
[2] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
[3] Natl Univ Ireland Univ Coll Cork, Sch Biochem, Cork, Ireland
来源：
基金：
爱尔兰科学基金会;
美国国家卫生研究院;
关键词：
PRF;
EBV;
POLY-Q;
HHV8;
HHV4;
SARCOMA-ASSOCIATED HERPESVIRUS;
LATENT NUCLEAR ANTIGEN;
KAPOSIS-SARCOMA;
NONCANONICAL TRANSLATION;
INHIBITION;
HUMAN-HERPESVIRUS-8;
IDENTIFICATION;
POLYALANINE;
RIBOSOMES;
EVOLUTION;
D O I：
10.1073/pnas.1416122111
中图分类号：
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号：
07 ;
0710 ;
09 ;
摘要：
Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) are human DNA tumor viruses that express nuclear antigens [latency-associated nuclear antigen 1 (LANA1) and Epstein-Barr nuclear antigen 1 (EBNA1)] necessary to maintain and replicate the viral genome. We report here that both LANA1 and EBNA1 undergo highly efficient +1/-2 programmed ribosomal frameshifting to generate previously undescribed alternative reading frame (ARF) proteins in their repeat regions. EBNA1(ARF) encodes a KSHV LANA-like glutamine- and glutamic acid-rich protein, whereas KSHV LANA1(ARF) encodes a serine/arginine-like protein. Repeat sequence recoding has not been described previously for human DNA viruses. Programmed frameshifting (recoding) to generate multiple proteins from one RNA sequence can increase the coding capacity of a virus, without incurring a selective penalty against increased capsid size. The presence of similar repeat sequences in cellular genes, such as huntingtin, suggests that a comparison of repeat recoding in virus and human systems may provide functional and mechanistic insights for both systems.
引用
收藏
页码：E4342 / E4349
页数：8
相关论文