Allergy and Chronic Obstructive Pulmonary Disease

被引:3
作者
Jin, Jian-Min [1 ]
Sun, Yong-Chang [2 ]
机构
[1] Capital Med Univ, Beijing Tongren Hosp, Dept Resp & Crit Care Med, Beijing 100730, Peoples R China
[2] Peking Univ, Dept Resp & Crit Care Med, Hosp 3, Beijing 100191, Peoples R China
基金
中国国家自然科学基金;
关键词
Allergy; Chronic Obstructive Pulmonary Disease; Phenotype; SHORT-TERM RESPONSE; SPUTUM-EOSINOPHILIA; SERUM IGE; CORTICOSTEROID TREATMENT; RESPIRATORY SYMPTOMS; BLOOD EOSINOPHILS; CONTROLLED-TRIAL; LUNG-FUNCTION; COPD; EXACERBATIONS;
D O I
10.4103/0366-6999.213427
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Allergy, airway hyperreactivity (AHR), and allergic asthma are risk factors of chronic obstructive pulmonary disease (COPD), a heterogeneous disease presenting with various phenotypes. An allergic phenotype of COPD, characterized by more severe respiratory symptoms and higher risk of acute exacerbations, was described recently.([1]) Further investigations into the role of allergy in the pathogenesis and/or expressions of COPD may lead to new modalities targeting the allergic component, a potentially treatable feature of a progressive disease like COPD.
引用
收藏
页码:2017 / 2020
页数:4
相关论文
共 32 条
[1]   Factors Associated With Bronchiectasis in Patients With COPD [J].
Angel Martinez-Garcia, Miguel ;
Jose Soler-Cataluna, Juan ;
Donat Sanz, Yolanda ;
Catalan Serra, Pablo ;
Agramunt Lerma, Marcos ;
Ballestin Vicente, Javier ;
Perpina-Tordera, Miguel .
CHEST, 2011, 140 (05) :1130-1137
[2]   Blood Eosinophils and Outcomes in Severe Hospitalized Exacerbations of COPD [J].
Bafadhel, Mona ;
Greening, Neil J. ;
Harvey-Dunstan, Theresa C. ;
Williams, Johanna E. A. ;
Morgan, Michael D. ;
Brightling, Christopher E. ;
Hussain, Syed F. ;
Pavord, Ian D. ;
Singh, Sally J. ;
Steiner, Michael C. .
CHEST, 2016, 150 (02) :320-328
[3]   Aspergillus fumigatus during stable state and exacerbations of COPD [J].
Bafadhel, Mona ;
Mckenna, Susan ;
Agbetile, Joshua ;
Fairs, Abbie ;
Desai, Dhananjay ;
Mistry, Vijay ;
Morley, Joseph P. ;
Pancholi, Mitesh ;
Pavord, Ian D. ;
Wardlaw, Andrew J. ;
Pashley, Catherine H. ;
Brightling, Christopher E. .
EUROPEAN RESPIRATORY JOURNAL, 2014, 43 (01) :64-71
[4]   Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease A Randomized Placebo-Controlled Trial [J].
Bafadhel, Mona ;
McKenna, Susan ;
Terry, Sarah ;
Mistry, Vijay ;
Pancholi, Mitesh ;
Venge, Per ;
Lomas, David A. ;
Barer, Michael R. ;
Johnston, Sebastian L. ;
Pavord, Ian D. ;
Brightling, Christopher E. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (01) :48-55
[5]   Acute Exacerbations of Chronic Obstructive Pulmonary Disease Identification of Biologic Clusters and Their Biomarkers [J].
Bafadhel, Mona ;
McKenna, Susan ;
Terry, Sarah ;
Mistry, Vijay ;
Reid, Carlene ;
Haldar, Pranabashis ;
McCormick, Margaret ;
Haldar, Koirobi ;
Kebadze, Tatiana ;
Duvoix, Annelyse ;
Lindblad, Kerstin ;
Patel, Hemu ;
Rugman, Paul ;
Dodson, Paul ;
Jenkins, Martin ;
Saunders, Michael ;
Newbold, Paul ;
Green, Ruth H. ;
Venge, Per ;
Lomas, David A. ;
Barer, Michael R. ;
Johnston, Sebastian L. ;
Pavord, Ian D. ;
Brightling, Christopher E. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 184 (06) :662-671
[6]   Mast Cell Infiltration Discriminates between Histopathological Phenotypes of Chronic Obstructive Pulmonary Disease [J].
Ballarin, Andrea ;
Bazzan, Erica ;
Hernandez Zenteno, Rafael ;
Turato, Graziella ;
Baraldo, Simonetta ;
Zanovello, Dora ;
Mutti, Elena ;
Hogg, James C. ;
Saetta, Marina ;
Cosio, Manuel G. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (03) :233-239
[7]   Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial [J].
Brightling, CE ;
Monteiro, W ;
Ward, R ;
Parker, D ;
Morgan, MDL ;
Wardlaw, AJ ;
Pavord, ID .
LANCET, 2000, 356 (9240) :1480-1485
[8]   Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease [J].
Brightling, CE ;
McKenna, S ;
Hargadon, B ;
Birring, S ;
Green, R ;
Siva, R ;
Berry, M ;
Parker, D ;
Monteiro, W ;
Pavord, ID ;
Bradding, P .
THORAX, 2005, 60 (03) :193-198
[9]   Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study [J].
Brightling, Christopher E. ;
Bleecker, Eugene R. ;
Panettieri, Reynold A., Jr. ;
Bafadhel, Mona ;
She, Dewei ;
Ward, Christine K. ;
Xu, Xiao ;
Birrell, Claire ;
van der Merwe, Rene .
LANCET RESPIRATORY MEDICINE, 2014, 2 (11) :891-901
[10]   Asthma-COPD Overlap [J].
Christenson, Stephanie A. ;
Steiling, Katrina ;
van den Berge, Maarten ;
Hijazi, Kahkeshan ;
Hiemstra, Pieter S. ;
Postma, Dirkje S. ;
Lenburg, Marc E. ;
Spira, Avrum ;
Woodruff, Prescott G. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 191 (07) :758-766