Synthesis and Antiproliferative Activity of Novel Hydrazono Thiazolidene and Thiazole Derivatives Bearing Rhodanine Moiety

被引：6

作者：

Elasasy, M. E. A. ^{[1
]}

Elnaggar, D. H. ^{[1
]}

Hafez, N. A. Abdel ^{[1
]}

Azab, M. E. ^{[2
]}

Amr, A. E. ^{[3
,4
]}

Omran, M. M. ^{[5
]}

Mohamed, A. M. ^{[1
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt

[2] Ain Shams Univ, Fac Sci, Chem Dept, Cairo 11566, Egypt

[3] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, Drug Explorat & Dev Chair DEDC, Riyadh 11451, Saudi Arabia

[4] Natl Res Ctr, Organ Chem Dept, Chem Ind Res Div, Cairo 12622, Egypt

[5] Cairo Univ, Natl Canc Inst, Canc Biol Dept, Pharmacol Unit, Cairo 11796, Egypt

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 05期

关键词：

thiosemicarbazone; thiazole; pyridine; antitumor activity; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; IN-VITRO; THIOSEMICARBAZONE; INHIBITORS; PYRAZOLE; DESIGN;

D O I：

10.1134/S1070363221050236

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some new fluoro-heterocyclic compounds containing thiazole and pyridine moities have been synthesized and studied for their antiproliferative activity. Thiazole derivatives have been synthesized by the reaction of alpha-halo carbonyl compounds with thiosemicarbazones. Some pyridine derivatives have been synthesized by the reaction of chalcone with cyanothioacetamide and/or malononitrile. Spectroscopic methods have been used for elucidating molecular structures of the products. Cytotoxic activity of several derivatives has been tested against human breast cancer (MCF-7), human colon cancer (HCT-116) and human liver cancer (Hep-G2) by the SRB method. Most of compounds exhibit mild effect on the tested cell lines. One of thiazolidin-4-one derivatives has been characterized by moderate to strong effect on MCF-7 cell line.

引用

页码：915 / 925

页数：11

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