Aberrant Changes of Wnt2/β-Catenin Signaling Pathway Induced by Sodium Nitroprusside in Human Esophageal Squamous Cell Carcinoma Cell Lines

被引：20

作者：

Wang, Wei ^{[1
]}

Xue, Lexun ^{[1
,2
]}

Liu, Hongtao ^{[2
]}

Wang, Pengju ^{[3
]}

Xu, Peirong ^{[2
]}

Cai, Yurong ^{[3
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Cell Biol Lab, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Dept Biol, Zhengzhou 450001, Henan, Peoples R China

[3] Zhengzhou Univ, Coll Basical Med, Zhengzhou 450001, Henan, Peoples R China

来源：

CANCER INVESTIGATION | 2010年 / 28卷 / 03期

关键词：

Wnt2/beta-catenin; Sodium nitroprusside; siRNA; Apoptosis; Esophageal squamous cell carcinoma; BETA-CATENIN; COLORECTAL-CANCER; EXPRESSION; GENE; INHIBITION; ACTIVATION; APOPTOSIS; CADHERIN; GROWTH;

D O I：

10.3109/07357900903095698

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inhibition of Wnt/beta-catenin pathway is an attractive method for therapy of various tumors including breast, colorectal, and cervical cancer, etc. However, little is known about the role of Wnt2/beta-catenin pathway in esophageal squamous cell carcinoma (ESCC). Here we identify that Wnt2/beta-catenin signaling pathway is activated in ESCC cells, and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1, but induce cell cycle arrest and apoptosis, suggesting that Wnt2/beta-catenin pathway may be a potential molecular target for ESCC therapy.

引用

页码：230 / 241

页数：12

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