Multiple types of logic gates based on a single G-quadruplex DNA strand

被引：42

作者：

Guo, Yahui ^{[1
,2
]}

Zhou, Lu ^{[1
]}

Xu, Lijun ^{[1
]}

Zhou, Xiaodong ^{[2
]}

Hu, Jiming ^{[2
]}

Pei, Renjun ^{[1
]}

机构：

[1] Chinese Acad Sci, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed,Key Lab Nanobio Interface, Suzhou 215123, Peoples R China

[2] Wuhan Univ, Coll Chem & Mol Sci, Key Lab Analyt Chem Biol & Med, Minist Educ, Wuhan 430072, Peoples R China

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

基金：

中国国家自然科学基金;

关键词：

LABEL-FREE DETECTION; HG2+; DISPLACEMENT; COMPUTATION; COMPLEXES; APTAMERS; MOTIFS; LEAD;

D O I：

10.1038/srep07315

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this work, we demonstrate the use of a single DNA strand and G-quadruplex-specific dye NMM as a label-free switch for the construction of series of basic logic gates (YES, NOT, OR, INHIBIT, NOR, AND). The simple GT-rich sequence could be used to interact with several molecules (K+, thrombin, Hg2+, and Pb2+) to form different structures that can be distinguished by the label-free dye NMM. Our study showed that a single G-qudruplex DNAstrand can function as multiple types of one-input and two-input logic gates with different combinations of input molecules.

引用

页数：6

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