Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients

被引：61

作者：

Espitia, Olivier ^{[1
]}

Samson, Maxime ^{[2
]}

Le Gallou, Thomas ^{[3
]}

Connault, Jerome ^{[1
]}

Landron, Cedric ^{[4
]}

Lavigne, Christian ^{[5
]}

Belizna, Cristina ^{[5
]}

Magnant, Julie ^{[6
]}

de Moreuil, Claire ^{[7
]}

Roblot, Pascal ^{[4
]}

Maillot, Francois ^{[6
]}

Diot, Elisabeth ^{[6
]}

Jego, Patrick ^{[3
]}

Durant, Cecile ^{[1
]}

Masseau, A. ^{[1
]}

Brisseau, Jean-Marie ^{[1
]}

Pottier, Pierre ^{[1
]}

Espitia-Thibault, Alexandra ^{[1
]}

Dos Santos, Anabele ^{[8
]}

Perrin, Francois ^{[1
]}

Artifoni, Mathieu ^{[1
]}

Neel, Antoine ^{[1
]}

Graveleau, Julie ^{[9
]}

Moreau, Philippe ^{[10
]}

Maisonneuve, Herve ^{[11
]}

Fau, Georges ^{[12
]}

Serfaty, Jean-Michel ^{[12
]}

Hamidou, Mohamed ^{[1
]}

Agard, Christian ^{[1
]}

机构：

[1] Univ Hosp Nantes, Dept Diagnost Cardiovasc Imaging, Nantes, France

[2] Univ Hosp Dijon, Dept Internal Med & Clin Immunol, Dijon, France

[3] Univ Hosp Rennes, Dept Internal Med, Rennes, France

[4] Univ Hosp Poitiers, Dept Internal Med, Poitiers, France

[5] Univ Hosp Angers, Dept Internal Med, Angers, France

[6] CHRU Tours, Dept Internal Med, Tours, France

[7] Univ Hosp Brest, Dept Internal Med, Brest, France

[8] Hosp Vannes, Dept Hematol, Vannes, France

[9] Hosp St Nazaire, Dept Med, St Nazaire, France

[10] Hosp Lorient, Dept Hematol, Lorient, France

[11] Hosp La Roche Sur Yon, Dept Hematol, La Roche Sur Yon, France

[12] Univ Hosp Nantes, Dept Radiol, Nantes, France

来源：

AUTOIMMUNITY REVIEWS | 2016年 / 15卷 / 06期

关键词：

Aortitis; Giant cell arteritis; Idiopathic aortitis; Isolated aortitis; Aortic aneurysm; LARGE-VESSEL INVOLVEMENT; RHEUMATOLOGY; 1990; CRITERIA; TERM-FOLLOW-UP; TEMPORAL ARTERITIS; SURGICAL PATHOLOGY; VASCULITIS; CLASSIFICATION; DIAGNOSIS; COMPLICATIONS; MANAGEMENT;

D O I：

10.1016/j.autrev.2016.02.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objectives: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis. Methods: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall, thickening >2 mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared. Results: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p = 0.003) and comprised more past/current smokers (43 vs 15%, p = 0.0007). Aortic aneurisms were more frequent (38% vs 20%, p = 0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median = 34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p = 0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p = 0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA >= 60 years when compared to patients with GCA-related aortitis. Conclusions: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients <60 years. Most patients with IA >= 60 years share many features with GCA-related aortitis. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：571 / 576

页数：6

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