α-C(sp3)-H Arylation of Cyclic Carbonyl Compounds

被引：6

作者：

Wang, Mei ^{[1
]}

Wang, Wei ^{[1
]}

Li, Dashan ^{[1
]}

Wang, Wen-Jing ^{[1
]}

Zhan, Rui ^{[2
]}

Shao, Li-Dong ^{[1
]}

机构：

[1] Yunnan Univ Chinese Med, Sch Chinese Mat Med, Yunnan Key Lab Southern Med Utilizat, Kunming 650050, Yunnan, Peoples R China

[2] Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650050, Yunnan, Peoples R China

来源：

NATURAL PRODUCTS AND BIOPROSPECTING | 2021年 / 11卷 / 04期

关键词：

C-H functionalization; alpha-C(sp3)-H arylation; Cyclic carbonyl compounds; CATALYZED ALPHA-ARYLATION; C-H FUNCTIONALIZATION; ASYMMETRIC ARYLATION; VINYLOGOUS ESTERS; CONCISE SYNTHESIS; FACILE SYNTHESIS; SIMPLE OLEFINS; ARYL HALIDES; PALLADIUM; KETONES;

D O I：

10.1007/s13659-021-00312-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

alpha-C(sp(3))-H arylation is an important type of C-H functionalization. Various biologically significant natural products, chemical intermediates, and drugs have been effectively prepared via C-H functionalization. Cyclic carbonyl compounds comprise of cyclic ketones, enones, lactones, and lactams. The alpha-C(sp(3))-H arylation of these compounds have been exhibited high efficiency in forming C(sp(3))-C(sp(2)) bonds, played a crucial role in organic synthesis, and attracted majority of interests from organic and medicinal communities. This review focused on the most significant advances including methods, mechanism, and applications in total synthesis of natural products in the field of alpha-C(sp(3))-H arylations of cyclic carbonyl compounds in recent years.

引用

页码：379 / 404

页数：26

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