Secondary Metabolites from Inula britannica L. and Their Biological Activities

被引：86

作者：

Khan, Abdul Latif ^{[1
,2
]}

Hussain, Javid ^{[2
]}

Hamayun, Muhammad ^{[1
]}

Gilani, Syed Abdullah ^{[4
]}

Ahmad, Shabir ^{[2
]}

Rehman, Gauhar ^{[3
]}

Kim, Yoon-Ha ^{[1
]}

Kang, Sang-Mo ^{[1
]}

Lee, In-Jung ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Appl Biosci, Taegu, South Korea

[2] Kohat Univ Sci & Technol, Dept Chem, Kohat, Pakistan

[3] Kyungpook Natl Univ, Sch Life Sci & Biotechnol, Dept Genet Engn, Taegu, South Korea

[4] Kohat Univ Sci & Technol, Dept Biotechnol, Kohat, Pakistan

来源：

MOLECULES | 2010年 / 15卷 / 03期

关键词：

I; britannica; sesquiterpenoids; flavonoids; triterpenoids; anticancer; antioxidant; anti-inflammatory; hepatoprotective; neuroprotective; NF-KAPPA-B; SESQUITERPENE LACTONES; ANTITUMOR-ACTIVITY; SIGNALING PATHWAY; PLANTS; ANTIOXIDANT; CELLS; MICE; ACTIVATION; FLAVONOIDS;

D O I：

10.3390/molecules15031562

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inula britannica L., family Asteraceae, is used in traditional Chinese and Kampo Medicines for various diseases. Flowers or the aerial parts are a rich source of secondary metabolites. These consist mainly of terpenoids (sesquiterpene lactones and dimmers, diterpenes and triterpenoids) and flavonoids. The isolated compounds have shown diverse biological activities: anticancer, antioxidant, anti-inflammatory, neuroprotective and hepatoprotective activities. This review provides information on isolated bioactive phytochemicals and pharmacological potentials of I. britannica.

引用

页码：1562 / 1577

页数：16

共 80 条

[31]

Khan A.L., 2008, MONOGRAPH INULA BRIT, P21

[32]

Khan Abdul Latif, 2008, Pakistan Journal of Scientific and Industrial Research, V51, P343

[33]

Kim Jinwoong, 2002, Current Medicinal Chemistry - Anti-Cancer Agents, V2, P485

[34] Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate [J].