Secondary Metabolites from Inula britannica L. and Their Biological Activities

被引：86

作者：

Khan, Abdul Latif ^{[1
,2
]}

Hussain, Javid ^{[2
]}

Hamayun, Muhammad ^{[1
]}

Gilani, Syed Abdullah ^{[4
]}

Ahmad, Shabir ^{[2
]}

Rehman, Gauhar ^{[3
]}

Kim, Yoon-Ha ^{[1
]}

Kang, Sang-Mo ^{[1
]}

Lee, In-Jung ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Appl Biosci, Taegu, South Korea

[2] Kohat Univ Sci & Technol, Dept Chem, Kohat, Pakistan

[3] Kyungpook Natl Univ, Sch Life Sci & Biotechnol, Dept Genet Engn, Taegu, South Korea

[4] Kohat Univ Sci & Technol, Dept Biotechnol, Kohat, Pakistan

来源：

MOLECULES | 2010年 / 15卷 / 03期

关键词：

I; britannica; sesquiterpenoids; flavonoids; triterpenoids; anticancer; antioxidant; anti-inflammatory; hepatoprotective; neuroprotective; NF-KAPPA-B; SESQUITERPENE LACTONES; ANTITUMOR-ACTIVITY; SIGNALING PATHWAY; PLANTS; ANTIOXIDANT; CELLS; MICE; ACTIVATION; FLAVONOIDS;

D O I：

10.3390/molecules15031562

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inula britannica L., family Asteraceae, is used in traditional Chinese and Kampo Medicines for various diseases. Flowers or the aerial parts are a rich source of secondary metabolites. These consist mainly of terpenoids (sesquiterpene lactones and dimmers, diterpenes and triterpenoids) and flavonoids. The isolated compounds have shown diverse biological activities: anticancer, antioxidant, anti-inflammatory, neuroprotective and hepatoprotective activities. This review provides information on isolated bioactive phytochemicals and pharmacological potentials of I. britannica.

引用

页码：1562 / 1577

页数：16

共 80 条

[1]

Ali SI, 1992, FLORA PAKISTAN ASTER, V210, P71

[2]

[Anonymous], 2006, Lyonia

[3] Synthesis of S-containing derivatives of the sesquiterpene lactone britanin [J].

Artemova, NP ;

Nikitina, LE ;

Yushkov, DA ;

Shigabutdinova, OG ;

Plemenkov, VV ;

Klochkov, VV ;

Khairutdinov, BI .

CHEMISTRY OF NATURAL COMPOUNDS, 2005, 41 (01) :45-47

[4]

BAI N, 2000, P 219 ACS NAT M SAN, P89

[5] Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines [J].

Bai, NS ;

Lai, CS ;

He, K ;

Zhou, Z ;

Zhang, L ;

Quan, Z ;

Zhu, NQ ;

Zheng, QY ;

Pan, MH ;

Ho, CT .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (04) :531-535

[6] Antioxidative flavonoids from the flower of Inula britannica [J].

Bai, NS ;

Zhou, Z ;

Zhu, NQ ;

Zhang, L ;

Quan, Z ;

He, K ;

Zheng, QY ;

Ho, CT .

JOURNAL OF FOOD LIPIDS, 2005, 12 (02) :141-149

[7]

Bai NS, 2003, ACS SYM SER, V859, P271

[8]

BOWN D, 1995, ENCY HERBS THEIR USE, P293

[9]

CHEVALLIER A, 1996, ENCY MED PLANTS, P301

[10]

Chugnov P.V., 1971, KHIM PRIROD SOED, V7, P276, DOI [10.1007/BF00568995, DOI 10.1007/BF00568995]

← 1 2 3 4 5 6 7 8 →