Trophoblast CD200 expression in successful human pregancies and missed abortions

被引：6
|
作者：
Clark, David A. [1 ,2 ]
McCready, M. Elizabeth [2 ,3 ]
Harris, Kate [3 ]
Malloy, Leslie [3 ]
Arredondo, Jorge L. [2 ]
机构：
[1] McMaster Univ, Dept Med, HSC Rm 3H1E, Hamilton, ON L8S 4K1, Canada
[2] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada
[3] McMaster Univ, Hamilton Hlth Sci, Hamilton Reg Lab Med Program, Cytogenet Lab,Med Ctr, 1200 Main St E, Hamilton, ON L8N 3Z5, Canada
来源：
JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2018年 / 127卷
关键词：
CD200; Missed abortion; receptors; Placenta; Trophoblasts; RECEPTOR FAMILY;
D O I：
10.1016/j.jri.2018.03.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Presence of the CD200 immune check-point inhibitor at the feto-maternal interface is linked to prevention of spontaneous abortion in mice and humans. In human missed abortions (MA), absence of Th17-driven inflammation has been attributed to expression of villus trophoblast CD200 quantified using immunohistochemistry. While rapid aneuploidy (QF-PCR) testing linked low CD200 to pregnancy failure, data showing normal VT CD200 in first trimester normal pregnancy and in abortion of chromosomally abnormal embryos has not been demonstrated. The present report shows normal CD200 in a 7 week gestation termination with normal male QF-PCR and in a 10 week male trisomy 18 MA.
引用
收藏
页码：55 / 57
页数：3
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