Region- and Layer-Specific Activation of the Higher Order Auditory Cortex Te2 after Remote Retrieval of Fear or Appetitive Memories

被引:12
作者
Grosso, Anna [1 ]
Cambiaghi, Marco [1 ]
Milano, Luisella [1 ]
Renna, Annamaria [1 ]
Sacco, Tiziana [1 ]
Sacchetti, Benedetto [1 ,2 ]
机构
[1] Univ Turin, Rita Levi Montalcini Dept Neurosci, Corso Raffaello 30, I-10125 Turin, Italy
[2] Natl Inst Neurosci Turin, I-10125 Turin, Italy
基金
欧洲研究理事会;
关键词
auditory cortex; cortical circuits; emotional learning; expression of immediate early genes; long-term memory; ANTERIOR CINGULATE CORTEX; RAT TEMPORAL CORTEX; LATERAL AMYGDALA; MEDIAL GENICULATE; CONDITIONED FEAR; C-FOS; PLASTICITY; EXPRESSION; NEURONS; INHIBITION;
D O I
10.1093/cercor/bhw159
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The auditory cortex is involved in encoding sounds which have acquired an emotional-motivational charge. However, the neural circuitry engaged by emotional memory processes in the auditory cortex is poorly understood. In this study, we investigated the layers and regions that are recruited in the higher order auditory cortex Te2 by a tone previously paired to either fear or appetitive stimuli in rats. By tracking the protein coded by the immediate early gene zif268, we found that fear memory retrieval engages layers II-III in most regions of Te2. These resultswere neither due to an enhanced fear state nor to fear-evoked motor responses, as they were absent in animals retrieving an olfactory fear memory. These layers were also activated by appetitive auditory memory retrieval. Strikingly, layer IV was recruited by fear, but not appetitive memories, whereas layer V activity was related to the behavioral responses displayed to the CS. In addition to revealing the layers and regions that are recruited in the Te2 by either fear or appetitive remote memories, our study also shows that the neural circuitry within the Te2 that processes and stores emotional memories varies on the basis of the affective motivational charge of tones.
引用
收藏
页码:3140 / 3151
页数:12
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