Peripheral immune phenotypes and T cell receptor repertoire in pneumocystis pneumonia in HIV-1 infected patients

被引：2
作者：
Qiao, Luxin [1 ]
Cui, Xiao [2 ]
Jia, Lin [2 ]
Gao, Yuxue [1 ]
Wang, Wenjing [1 ]
Wei, Feili [1 ]
Zhang, Zhili [2 ]
Chen, Dexi [1 ]
Ma, Yingmin [2 ]
Zhang, Yulin [2 ,3 ]
机构：
[1] Capital Med Univ, Beijing You An Hosp, Beijing Inst Hepatol, Beijing 100069, Peoples R China
[2] Capital Med Univ, Beijing You An Hosp, Dept Resp & Infect Dis, Beijing 100069, Peoples R China
[3] Capital Med Univ, Beijing You An Hosp, Clin & Res Ctr Infect Dis, Beijing Key Lab HIV AIDS Res, Beijing 100069, Peoples R China
来源：
CLINICAL IMMUNOLOGY | 2022年 / 237卷
基金：
中国国家自然科学基金;
关键词：
High-throughput sequencing; HIV-1; Mass cytometry; Pneumocystis pneumonia; T cell receptor; MASS CYTOMETRY; EFFECTOR;
D O I：
10.1016/j.clim.2022.108985
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: The host immune response to pneumocystis pneumonia (PCP) involves interactions among immune cell subsets and cytokines. However, the definite pathogenesis and immunological influences of P. jirovecii have not been fully elucidated.Methods: Mass cytometry and high-throughput sequencing of the T cell receptor (TCR) were used to profile the host immune response to human immunodeficiency virus-1 (HIV-1) and P. jirovecii infection. Results: Our findings demonstrated that patients with PCP showed different immune cell proportions when compared to healthy controls. Changes in cytokines were found after anti-PCP treatment, suggested that cytokines may play an important role in controlling the pathogen. Furthermore, PCP patients showed marked reduction of TCR repertoire diversity. The diversity of TCR repertoire was restored by the anti-PCP treatment.Conclusion: In summary, we profiled the composition and characteristics of immune environment in response to HIV-1 and P. jirovecii infection, which may contribute to elucidating host immunity.
引用
收藏
页数：10
相关论文
共 45 条
  • [1] T-cell complexity and density are associated with sensitivity to neoadjuvant chemoradiotherapy in patients with rectal cancer
    Akiyoshi, Takashi
    Gotoh, Osamu
    Tanaka, Norio
    Kiyotani, Kazuma
    Yamamoto, Noriko
    Ueno, Masashi
    Fukunaga, Yosuke
    Mori, Seiichi
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2021, 70 (02) : 509 - 518
  • [2] Increased mRNA expression of key cytokines among suspected cases of Pneumocystis jirovecii infection
    Alshahrani, Mohammad Y.
    Alfaifi, Mohammed
    Al Shahrani, Mesfer
    Alshahrani, Abdulaziz S.
    Alkhathami, Ali G.
    Dera, Ayed A.
    Ahmad, Irfan
    Wahab, Shadma
    Beg, Mirza M. A.
    Hakamy, Ali
    Hamid, Mohamed E.
    [J]. BMC INFECTIOUS DISEASES, 2021, 21 (01)
  • [3] Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment
    Azizi, Elham
    Carr, Ambrose J.
    Plitas, George
    Cornish, Andrew E.
    Konopacki, Catherine
    Prabhakaran, Sandhya
    Nainys, Juozas
    Wu, Kenmin
    Kiseliovas, Vaidotas
    Setty, Manu
    Choi, Kristy
    Fromme, Rachel M.
    Phuong Dao
    McKenney, Peter T.
    Wasti, Ruby C.
    Kadaveru, Krishna
    Mazutis, Linas
    Rudensky, Alexander Y.
    Pe'er, Dana
    [J]. CELL, 2018, 174 (05) : 1293 - +
  • [4] Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
    Bendall, Sean C.
    Simonds, Erin F.
    Qiu, Peng
    Amir, El-ad D.
    Krutzik, Peter O.
    Finck, Rachel
    Bruggner, Robert V.
    Melamed, Rachel
    Trejo, Angelica
    Ornatsky, Olga I.
    Balderas, Robert S.
    Plevritis, Sylvia K.
    Sachs, Karen
    Pe'er, Dana
    Tanner, Scott D.
    Nolan, Garry P.
    [J]. SCIENCE, 2011, 332 (6030) : 687 - 696
  • [5] Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision
    Bongomin, Felix
    Gago, Sara
    Oladele, Rita O.
    Denning, David W.
    [J]. JOURNAL OF FUNGI, 2017, 3 (04)
  • [6] AIDS-defining opportunistic illnesses in US patients, 1994-2007: a cohort study
    Buchacz, Kate
    Baker, Rose K.
    Palella, Frank J., Jr.
    Chmiel, Joan S.
    Lichtenstein, Kenneth A.
    Novak, Richard M.
    Wood, Kathleen C.
    Brooks, John T.
    [J]. AIDS, 2010, 24 (10) : 1549 - 1559
  • [7] The importance of pro-inflammatory and anti-inflammatory cytokines in Pneumocystis jirovecii pneumonia
    Chou, Chung-Wei
    Lin, Fang-Chi
    Tsai, Han-Chen
    Chang, Shi-Chuan
    [J]. MEDICAL MYCOLOGY, 2013, 51 (07) : 704 - 712
  • [8] Unraveling cell populations in tumors by single-cell mass cytometry
    Di Palma, Serena
    Bodenmiller, Bernd
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2015, 31 : 122 - 129
  • [9] Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia
    Gigliotti, Francis
    Crow, Elliott L.
    Bhagwat, Samir P.
    Wright, Terry W.
    [J]. INFECTION AND IMMUNITY, 2006, 74 (11) : 6310 - 6316
  • [10] Deciphering the TCR Repertoire to Solve the COVID-19 Mystery
    Gutierrez, Lucas
    Beckford, John
    Alachkar, Houda
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2020, 41 (08) : 518 - 530
12345