PARP inhibition: PARP1 and beyond

被引：1055
作者：
Rouleau, Michele [1 ]
Patel, Anand [2 ]
Hendzel, Michael J. [4 ]
Kaufmann, Scott H. [2 ,3 ]
Poirier, Guy G. [1 ]
机构：
[1] Univ Laval, Med Res Ctr, Quebec City, PQ, Canada
[2] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA
[3] Mayo Clin, Div Oncol Res, Rochester, MN USA
[4] Univ Alberta, Fac Med, Dept Oncol, Edmonton, AB T6G 2M7, Canada
来源：
NATURE REVIEWS CANCER | 2010年 / 10卷 / 04期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
POLY(ADP-RIBOSE) POLYMERASE INHIBITOR; ADENOSINE-DIPHOSPHATE-RIBOSE; DOUBLE-STRAND BREAKS; DNA-DAMAGING AGENTS; HUMAN GLIOMA-CELLS; HOMOLOGOUS RECOMBINATION; ADP-RIBOSYLATION; TELOMERE LENGTH; IN-VIVO; EMBRYONIC-DEVELOPMENT;
D O I：
10.1038/nrc2812
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.
引用
收藏
页码：293 / 301
页数：9
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