Posterior Reversible Encephalopathy Syndrome in Childhood Hematological/Oncological Diseases: Multicenter Results

被引:2
作者
Bilir, Ozlem A. [1 ]
Dikme, Gurcan [4 ]
Malbora, Baris [2 ,7 ]
Evim, Melike S. [9 ]
Sivis, Zuhal O. [7 ]
Tufekci, Ozlem [8 ]
Bahadir, Aysenur [10 ]
Karaman, Serap [5 ]
Vural, Sema [6 ]
Bayhan, Turan [3 ]
Yarali, Husniye N. [1 ]
Celkan, Tiraje [4 ]
Ozbek, Namik Y. [1 ]
机构
[1] Minist Hlth, Dept Pediat Hematol & Oncol, Ankara City Hosp, Bilkent Caddesi 1, TR-06800 Ankara, Turkey
[2] Baskent Univ, Dept Pediat Hematol, Fac Med, Ankara, Turkey
[3] Dr Abdurrahman Yurtaslan Ankara Oncol Training &, Pediat Hematol & Oncol, Ankara, Turkey
[4] Istanbul Univ, Cerrahpasa Fac Med, Dept Pediat Hematol Oncol, Istanbul, Turkey
[5] Istanbul Univ, Med Fac, Istanbul, Turkey
[6] Univ Hlth Sci, Pediat Hematol & Oncol, Istanbul Hamidiye Sisli Etfal Training & Res Hosp, Istanbul, Turkey
[7] Tepecik Educ & Training Hosp, Dept Pediat Hematol & Oncol, Izmir, Turkey
[8] Dokuz Eylul Univ, Dept Pediat Hematol, Med Fac, Izmir, Turkey
[9] Uludag Univ, Pediat Hematol & Oncol, Med Fac, Bursa, Turkey
[10] Karadeniz Tech Univ, Fac Med, Dept Pediat Haematol, Trabzon, Turkey
关键词
child; PRES; encephalopathy; hematologic disease; hypertension; NERVOUS-SYSTEM COMPLICATIONS; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELL; CHILDREN; PRES; LEUKOENCEPHALOPATHY; MANIFESTATIONS; CHEMOTHERAPY;
D O I
10.1097/MPH.0000000000001965
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of the study was to analyze the characteristics of posterior reversible encephalopathy syndrome (PRES) cases treated at 10 different institutions in our country. Fifty-eight patients diagnosed with PRES were included in this study. The data of PRES cases from 10 departments of pediatric hematology/oncology were analyzed. The mean age of the patients at the time of diagnosis of PRES was 8.95 +/- 3.66 years. Most patients (80.4%) had a primary diagnosis of acute leukemia. Patients received chemotherapy (71.4%) and/or used steroids within 14 days before the diagnosis of PRES (85.7%). Hypertension was found in 83.9% of the patients. Twenty-six patients had infections and 22 of them had febrile neutropenia. The most common electrolyte disorders were hypocalcemia, hypomagnesemia, and hypopotassemia. Six patients had tumor lysis syndrome and 4 had inappropriate antidiuretic hormone syndrome. Magnetic resonance imaging was used for diagnosis in all patients. The most commonly involved regions by magnetic resonance imaging were occipital (58%), parietal (51%), and frontal lobes (45%), respectively. Twenty-five patients required intensive care and 7 patients were intubated. In conclusion, PRES may develop during the follow-up and treatment of hematological diseases. In addition to steroid and intense combined chemotherapies, immunosuppressive agents and hypertension are also factors that may be responsible for PRES.
引用
收藏
页码:E462 / E465
页数:4
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