Iridium-Catalyzed B-H Bond Insertion Reactions Using Sulfoxonium Ylides as Carbene Precursors toward α-Boryl Carbonyls

被引：67
|
作者：
Li, Jianglian [1 ,2 ]
He, Hua [1 ,2 ]
Huang, Mengyi [1 ,2 ]
Chen, Yuncan [1 ,2 ]
Luo, Yi [1 ,2 ]
Yan, Kaichuan [1 ,2 ]
Wang, Qiantao [1 ,2 ]
Wu, Yong [1 ,2 ]
机构：
[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist,Sichuan Engn Lab Plant Sourced Drug, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Sichuan, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 22期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1021/acs.orglett.9b03410
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An iridium-catalyzed B-H bond insertion reaction between borane adducts and sulfoxonium ylides to afford alpha-boryl carbonyls has been developed. The starting materials are safe and readily available. In addition, analogues of sulfoxonium ylides, such as sulfonium salts and sulfonium ylides could also be amenable to the reaction.
引用
收藏
页码：9005 / 9008
页数：4
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