ObjectiveTo evaluate the parameters which predict the success or failure of trial without catheter (TWOC) for acute urine retention (AUR). Materials and methodsMedical records of 2188 patients presenting with first episode of AUR were analyzed. All patients underwent catheterization and were started on -blocker followed by TWOC. Age, baseline American urological association (AUA) score, prostate volume (PV), residual volume of urine (RV) and intravesical prostatic protrusion (IPP), prostate specific antigen (PSA) were recorded. ResultsTWOC was successful in 737 patients (33.7%) and failed in 1451 patients (66.3%). Patients with successful TWOC had lower mean age, PV, IPP, RV, AUA score, and PSA than those with failed TWOC. On multivariate analysis, the significant independent predictors were IPP, age, AUA score, PV, and RV at odds ratios of 3.11, 1.84, 1.78, 1.53, and 1.23, respectively. From ROC curve, IPP had cut off value of 9mm and detected success of TWOC with sensitivity (S) of 91% and failure with specificity (s) of 90%. Similarly, cut off value of 64 years for age (S:86%, s:87%), 20 for AUA symptom score (S:83%, s:81%), 56cc for PV (S:80%, s:74%) and 750mL for RV (S:71%, s:68%) were obtained. ConclusionAge, baseline AUA score, IPP, PV, and RV independently predict the outcome of TWOC. Patients with IPP>9mm, age>65 years, baseline AUA score>20, PV>56cc, or RV>750mL have less probability of successful TWOC in AUR and can be considered for immediate surgery following an episode of AUR.