Synthetic, spectral, thermal and antimicrobial studies on some mixed 1,3-dithia-2-stannacyclopentane derivatives with dialkyldithiocarbamates

1.3-Dithia-2-stannacyclopentane derivatives with dialkyldithiocarbamates of the types SCH2CH2SSn[(SCNR2)-C-2]Cl (I) and SCH2CH2SSn[S2CNR2](2) (II) (where R = CH3, C2H5 and -CH2,-CH2-) have been synthesized by the reaction of 2,2-dichloro-1,3-dithia-2-stannacyclopentane and sodium/ammonium salts of dialkyldithiocarbamates in 1:1 and 1:2 molar ratios, respectively, in anhydrous benzene. These newly synthesized derivatives have been characterized by elemental analyses (C, H, N, S and Sn), thermal [thermogravimetry (TG) and differential thermal analyses (DTA)] as well as spectral [UV, IR and multinuclear NMR (H-1, C-13 and Sn-119)] studies. The monodentate behaviour of the dialkyldithiocarabamate ligands was confirmed by IR and Sn-119 NMR spectral data and distorted tetrahedral structures have been suggested for both type (I) and (II) compounds. The free ligands and their tin complexes have also been screened for their antibacterial and antifungal activities. These results made it desirable to delineate a comparison between free ligands and their tin complexes. These exhibit higher antibacterial effect than some of the previously investigated antibiotics. (C) 2004 Elsevier B.V. All rights reserved.