Relationship between hyperhomocysteinemia and coexisting obesity with low skeletal muscle mass in asymptomatic adult population

被引:12
作者
Yoo, Tae Kyung [1 ]
Rhim, Hye Chang [1 ]
Lee, Yong-Taek [2 ]
Yoon, Kyung Jae [2 ,3 ]
Park, Chul-Hyun [2 ,3 ]
机构
[1] Tufts Univ, Dept Med, MetroWest Med Ctr, Sch Med, Framingham, MA USA
[2] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Phys & Rehabil Med, Sch Med, 29 Saemunanro, Seoul 03181, South Korea
[3] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
TOTAL HOMOCYSTEINE CONCENTRATIONS; SARCOPENIC OBESITY; METHYLENETETRAHYDROFOLATE REDUCTASE; PHYSICAL PERFORMANCE; INSULIN-RESISTANCE; BODY-COMPOSITION; NATIONAL-HEALTH; RISK; PREVALENCE; ACID;
D O I
10.1038/s41598-022-16401-1
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The relationship between hyperhomocysteinemia (HHcy) and obesity with low skeletal muscle mass (LMM) has not been established. We aim to assess the association between HHcy and the coexistence of obesity and LMM in asymptomatic adult population. We conducted a population-based cross-sectional study among asymptomatic individuals who underwent measurements of plasma homocysteine and body composition analysis. HHcy was defined as > 15 umol/L, obesity as body mass index >= 25 (kg/m(2)), and LMM as skeletal muscle index less than 2 SD below the sex-specific mean of young adults. The participants were classified into 'control', 'obesity alone', 'LMM alone', and 'obesity with LMM'. Among 113,805 participants, the prevalence of HHcy was 8.3% in control, 8.7% in obesity alone, 10.0% in LMM alone, and 13.0% in obesity with LMM (p for trend < 0.001). In a multivariable logistic regression analysis, the associations showed a positive trend for HHcy along the groups from obesity alone, to LMM alone, and to obesity with LMM. HHcy was independently associated with the presence of LMM alone (adjusted odds ratio 1.186 [95% confidence interval 1.117-1.259]) and obesity with LMM (1.424 [1.134-1.788]), respectively. This study demonstrated that HHcys was more strongly associated with coexistence of obesity and LMM than either condition alone in the adult population.
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页数:9
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