Cognitive Profile and its Association with Neuroimaging Markers of Non-Demented Cerebral Amyloid Angiopathy Patients in a Stroke Unit

被引:52
作者
Xiong, Li [1 ,2 ]
Davidsdottir, Sigurros [3 ]
Reijmer, Yael D. [1 ]
Shoamanesh, Ashkan [4 ]
Roongpiboonsopit, Duangnapa [1 ,5 ]
Thanprasertsuk, Sekh [6 ]
Martinez-Ramirez, Sergi [1 ]
Charidimou, Andreas [1 ]
Ayres, Alison M. [1 ]
Fotiadis, Panagiotis [1 ]
Gurol, Edip [1 ]
Blacker, Deborah L. [3 ]
Greenberg, Steven M. [1 ]
Viswanathan, Anand [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA
[2] Wuhan Univ, Zhongnan Hosp, Dept Neurol, Wuhan 430072, Peoples R China
[3] Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA
[4] McMaster Univ, Populat Hlth Res Inst, Dept Neurol, Hamilton, ON L8S 4L8, Canada
[5] Naresuan Univ, Dept Med, Phitsanulok, Thailand
[6] Chulalongkorn Univ, Dept Med, Bangkok, Thailand
关键词
Brain atrophy; cerebral amyloid angiopathy; cerebral microbleeds; clinical neuropsychology; cognitive impairment; hippocampal atrophy; intracranial hemorrhage; white matter hyperintensities; SMALL VESSEL DISEASE; MICROBLEEDS; IMPAIRMENT; HIPPOCAMPAL; PREVALENCE; DEMENTIA; ATROPHY; MEMORY; VALIDATION; HEMORRHAGE;
D O I
10.3233/JAD-150890
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Cerebral amyloid angiopathy (CAA) is increasingly recognized as a cause of cognitive impairment in the elderly, but the cognitive profile in patients with the disease has not been well characterized. Objective: To characterize the neuropsychological profile of CAA patients without dementia and to determine the association between cognitive performance in different domains and neuroimaging lesions characteristic of CAA. Methods: Fifty-eight non-demented CAA patients were compared to 138 cognitively normal subjects using a standard neuropsychological test battery. Total brain volume (TBV), white matter hyperintensities, number of lobar cerebral microbleeds, hippocampal volume, and cortical superficial siderosis in all CAA patients were assessed. The association between these neuroimaging markers and neuropsychological performance in different cognitive domains in the CAA group were analyzed. Results: Patients with CAA had significantly worse performance on all individual neuropsychological domains tested, when compared to the cognitive normal group. The cognitive decline of CAA patients was most noticeable in tests for processing speed with a Z score of -1.92 +/- 1.56 (mean +/- SD), then followed by executive function (-0.93 +/- 1.01), episodic memory (-0.87 +/- 1.29), semantic fluency (-0.73 +/- 1.06), and attention (-0.42 +/- 0.98). TBV of the CAA patients was correlated with processing speed (beta = 0.335, p = 0.03) and executive function (beta = 0.394, p = 0.01). Conclusions: Non-demented patients with CAA had cognitive deficits in multiple areas. Lower TBV was related to slower processing speed and worse executive function.
引用
收藏
页码:171 / 178
页数:8
相关论文
共 46 条
[41]   The neuropsychological profile of vascular cognitive impairment not demented: A meta-analysis [J].
Vasquez, Brandon P. ;
Zakzanis, Konstantine K. .
JOURNAL OF NEUROPSYCHOLOGY, 2015, 9 (01) :109-136
[42]   Prevalence and risk factors of cerebral microbleeds - The Rotterdam Scan Study [J].
Vernooij, M. W. ;
van der Lugt, A. ;
Ikram, M. A. ;
Wielopolski, P. A. ;
Niessen, W. J. ;
Hofman, A. ;
Krestin, G. P. ;
Breteler, M. M. B. .
NEUROLOGY, 2008, 70 (14) :1208-1214
[43]   Tissue microstructural changes are independently associated with cognitive impairment in cerebral amyloid angiopathy [J].
Viswanathan, Anand ;
Patel, Pratik ;
Rahman, Rosanna ;
Nandigam, R. N. Kaveer ;
Kinnecom, Catherine ;
Bracoud, Luc ;
Rosand, Jonathan ;
Chabriat, Hugues ;
Greenberg, Steven M. ;
Smith, Eric E. .
STROKE, 2008, 39 (07) :1988-1992
[44]   Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration [J].
Wardlaw, Joanna M. ;
Smith, Eric E. ;
Biessels, Geert J. ;
Cordonnier, Charlotte ;
Fazekas, Franz ;
Frayne, Richard ;
Lindley, Richard I. ;
O'Brien, John T. ;
Barkhof, Frederik ;
Benavente, Oscar R. ;
Black, Sandra E. ;
Brayne, Carol ;
Breteler, Monique ;
Chabriat, Hugues ;
DeCarli, Charles ;
de Leeuw, Frank-Erik ;
Doubal, Fergus ;
Duering, Marco ;
Fox, Nick C. ;
Greenberg, Steven ;
Hachinski, Vladimir ;
Kilimann, Ingo ;
Mok, Vincent ;
van Oostenbrugge, Robert ;
Pantoni, Leonardo ;
Speck, Oliver ;
Stephan, Blossom C. M. ;
Teipel, Stefan ;
Viswanathan, Anand ;
Werring, David ;
Chen, Christopher ;
Smith, Colin ;
van Buchem, Mark ;
Norrving, Bo ;
Gorelick, Philip B. ;
Dichgans, Martin .
LANCET NEUROLOGY, 2013, 12 (08) :822-838
[45]   The Neuropsychological Profile of Alzheimer Disease [J].
Weintraub, Sandra ;
Wicklund, Alissa H. ;
Salmon, David P. .
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (04)
[46]   Global brain atrophy but not hippocampal atrophy is related to type 2 diabetes [J].
Wisse, Laura E. M. ;
de Bresser, Jeroen ;
Geerlings, Mirjam I. ;
Reijmer, Yael D. ;
Portegies, Marileen L. P. ;
Brundel, Manon ;
Kappelle, L. Jaap ;
van der Graaf, Yolanda ;
Biessels, Geert Jan .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2014, 344 (1-2) :32-36