Spatial and latent memory data in PS2Tg2576 alzheimer's disease mouse model after memantine treatment

被引：1

作者：

Matsumura, Masahisa ^{[1
]}

Sato, Kana ^{[1
]}

Kubota, Takashi ^{[1
]}

Kishimoto, Yasushi ^{[1
,2
]}

机构：

[1] Tokushima Bunri Univ, Lab Neurobiophys, Kagawa Sch Pharmaceut Sci, Tokushima, Japan

[2] Teikyo Univ, Phys Chem Lab, Tokyo, Japan

来源：

DATA IN BRIEF | 2021年 / 36卷

关键词：

Alzheimer's disease; Latent memory; Memantine; Presenilin; 2; Spatial memory; IMPAIRMENT; MICE;

D O I：

10.1016/j.dib.2021.107131

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We herein present behavioral data on whether memantine, an adamantane derivative and medical NMDA-receptor antagonist, improves spatial and latent learning deficits in amyloid precursor protein/presenilin 2 double-transgenic mice (PS2Tg2576 mice). In PS2Tg2576 mice, early amyloid-beta protein (A beta) deposition at 2-3 months of age and progressive accumulation at about 5 months of age has been shown. Thus, PS2Tg2576 mice were subjected to Morris water maze (MWM) test for spatial memory and the water-finding test for latent memory testing at ages 3 and 5-6 months. In addition, memantine (30 mg/kg/day, p.o.) was administered 34 weeks before commencing the behavioral tasks to check for effects on cognitive function. The information provided in this paper adds to the literature and can be used for the selection of animal models and behavioral paradigms for Alzheimer's disease (AD) research. (C) 2021 The Author(s). Published by Elsevier Inc.

引用

页数：7

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