Twenty years' experience of laparoscopic 1-anastomosis gastric bypass: surgical risk and long-term results

Background: Laparoscopic 1- (single-) anastomosis gastric bypass (OAGB) was developed as a simplified technique of Roux-en-Y gastric bypass (RYGB), but super long-term data are lacking. Objectives: To evaluate the risks and long-term results of OAGB over a period of 20 years. Setting: Tertiary teaching hospital. Methods: Atotal of 2223 patients underwent OAGB from 2001 to 2020; the mean age was 35.3 +/- 11.4 years (range, 14-71 yr), 70.2% were female, and themean bodymass index was 40.2 +/- 11.9 kg/m(2). All data were kept in a prospective bariatric database. Patients were divided into 4 groups, based on the 5-year period in which their surgery was performed, and a retrospective analysis was conducted. Results: The means for operating time, intraoperative blood loss, and length of hospital stay after OAGB were 131.9 +/- 40.1 minutes, 38.5 +/- 30.7 mL, and 4.5 +/- 4.0 days, respectively. There were 27 patients (1.2%) with 30-day postoperative major complications overall, but the group rate decreased to.4% in the last 5-year period. At postoperative years 5, 10, and 15, the percentages of total weight loss were 31.9%, 29.6%, and 29.5%, respectively, and the percentages of excess weight loss were 77.2%, 68.4%, and 65.5%, respectively. Among 739 patients (33.2%) with type 2 diabetes (T2D), the rates of complete remission (glycated hemoglobin < 60%) at 5, 10, and 15 years were 67.3%, 73.8%, and 66.7%, respectively. The weight loss and antimetabolic effects were similar in each 5-year period, but a significant malnutrition effect was observed. A total of 113 (5.1%) patients needed revision surgery at follow-up, due to malnutrition (n = 51), weight regain (n = 24), acid or bile reflux (n = 22), marginal ulcer (n = 8), ileus (n = 3), and other causes (n = 5). At 15 years, the overall revision rate was 11.9% (27/226), and 80% of the patients were very satisfied with their procedures. Conclusion: Our results showed that OAGB is a safe and durable primary bariatric procedure, with sustained weight loss and a high resolution of T2D up to 20 years post surgery in Taiwan, although malnutrition is a major side effect. (C) 2021 Published by Elsevier Inc. on behalf of American Society for Bariatric Surgery.