Hidden in plain sight: promising therapeutic targets for glioblastoma lurk within DNA damage response pathways

被引:0
作者
Carruthers, Ross [1 ]
Chalmers, Anthony J. [1 ]
机构
[1] Univ Glasgow, Inst Canc Sci, Translat Radiat Biol, Glasgow, Lanark, Scotland
关键词
RADIATION-RESISTANCE; ATM; INHIBITION; RADIOSENSITIZATION; CELLS;
D O I
10.21037/tcr.2017.03.43
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:S438 / S440
页数:3
相关论文
共 16 条
[1]   Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells [J].
Ahmed, Shafiq U. ;
Carruthers, Ross ;
Gilmour, Lesley ;
Yildirim, Salih ;
Watts, Colin ;
Chalmers, Anthony J. .
CANCER RESEARCH, 2015, 75 (20) :4416-4428
[2]   Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells [J].
Barazzuol, Lara ;
Rickett, Nicole ;
Ju, Limei ;
Jeggo, Penny A. .
JOURNAL OF CELL SCIENCE, 2015, 128 (19) :3597-3606
[3]   Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas [J].
Bartkova, J. ;
Hamerlik, P. ;
Stockhausen, M-T ;
Ehrmann, J. ;
Hlobilkova, A. ;
Laursen, H. ;
Kalita, O. ;
Kolar, Z. ;
Poulsen, H. S. ;
Broholm, H. ;
Lukas, J. ;
Bartek, J. .
ONCOGENE, 2010, 29 (36) :5095-5102
[4]   ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation [J].
Biddlestone-Thorpe, Laura ;
Sajjad, Muhammad ;
Rosenberg, Elizabeth ;
Beckta, Jason M. ;
Valerie, Nicholas C. K. ;
Tokarz, Mary ;
Adams, Bret R. ;
Wagner, Alison F. ;
Khalil, Ashraf ;
Gilfor, Donna ;
Golding, Sarah E. ;
Deb, Sumitra ;
Temesi, David G. ;
Lau, Alan ;
O'Connor, Mark J. ;
Choe, Kevin S. ;
Parada, Luis F. ;
Lim, Sang Kyun ;
Mukhopadhyay, Nitai D. ;
Valerie, Kristoffer .
CLINICAL CANCER RESEARCH, 2013, 19 (12) :3189-3200
[5]   Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase [J].
Carruthers, Ross ;
Ahmed, Shafiq U. ;
Strathdee, Karen ;
Gomez-Roman, Natividad ;
Amoah-Buahin, Evelyn ;
Watts, Colin ;
Chalmers, Anthony J. .
MOLECULAR ONCOLOGY, 2015, 9 (01) :192-203
[6]  
Carruthers Ross, 2012, CNS Oncol, V1, P85, DOI 10.2217/cns.12.13
[7]   Science in Focus: Combining Radiotherapy with Inhibitors of the DNA Damage Response [J].
Chalmers, A. J. .
CLINICAL ONCOLOGY, 2016, 28 (05) :279-282
[8]   Comprehensive genomic characterization defines human glioblastoma genes and core pathways [J].
Chin, L. ;
Meyerson, M. ;
Aldape, K. ;
Bigner, D. ;
Mikkelsen, T. ;
VandenBerg, S. ;
Kahn, A. ;
Penny, R. ;
Ferguson, M. L. ;
Gerhard, D. S. ;
Getz, G. ;
Brennan, C. ;
Taylor, B. S. ;
Winckler, W. ;
Park, P. ;
Ladanyi, M. ;
Hoadley, K. A. ;
Verhaak, R. G. W. ;
Hayes, D. N. ;
Spellman, Paul T. ;
Absher, D. ;
Weir, B. A. ;
Ding, L. ;
Wheeler, D. ;
Lawrence, M. S. ;
Cibulskis, K. ;
Mardis, E. ;
Zhang, Jinghui ;
Wilson, R. K. ;
Donehower, L. ;
Wheeler, D. A. ;
Purdom, E. ;
Wallis, J. ;
Laird, P. W. ;
Herman, J. G. ;
Schuebel, K. E. ;
Weisenberger, D. J. ;
Baylin, S. B. ;
Schultz, N. ;
Yao, Jun ;
Wiedemeyer, R. ;
Weinstein, J. ;
Sander, C. ;
Gibbs, R. A. ;
Gray, J. ;
Kucherlapati, R. ;
Lander, E. S. ;
Myers, R. M. ;
Perou, C. M. ;
McLendon, Roger .
NATURE, 2008, 455 (7216) :1061-1068
[9]   Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control [J].
Golding, Sarah E. ;
Rosenberg, Elizabeth ;
Adams, Bret R. ;
Wignarajah, Shayalini ;
Beckta, Jason M. ;
O'Connor, Mark J. ;
Valerie, Kristoffer .
CELL CYCLE, 2012, 11 (06) :1167-1173
[10]   Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system [J].
Herzog, KH ;
Chong, MJ ;
Kapsetaki, M ;
Morgan, JI ;
McKinnon, PJ .
SCIENCE, 1998, 280 (5366) :1089-1091