Nuclear receptor ligands and cofactor recruitment: Is there a coactivator "On deck"?

被引：21

作者：

Nettles, KW ^{[1
]}

Greene, GL ^{[1
]}

机构：

[1] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA

来源：

MOLECULAR CELL | 2003年 / 11卷 / 04期

关键词：

D O I：

10.1016/S1097-2765(03)00133-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Farnesoid X receptor (FXR) is a bile acid sensor that regulates lipid homeostasis. New structural data suggest that, unlike other nuclear receptors, FXR contains a second coactivator binding site and binds bile acids with the steroid backbone flipped head to tail, both of which have important functional ramifications.

引用

页码：850 / 851

页数：2

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