Needle-based reflection refractometry of scattering samples using coherence-gated detection

被引:19
作者
Zysk, Adam M. [1 ]
Marks, Daniel L. [1 ]
Liu, Dianna Y. [1 ]
Boppart, Stephen A. [1 ]
机构
[1] Univ Illinois, Mills Breast Canc Inst, Carle Fdn Hosp, Urbana, IL 61801 USA
关键词
D O I
10.1364/OE.15.004787
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We present a novel method for in situ refractive index measurement of scattering samples using a needle device. The device employs a fiber-based reflectance refractometer and coherence-gated detection of the reflected optical signal that eliminates scattering-dependent backreflection contributions. Additionally, birefringence changes induced by fiber movement are neutralized by randomizing the source polarizations and averaging the measured Fresnel reflection coefficients over many incident polarization states. Experimental measurements of Intralipid scattering solutions are presented and compared with Monte Carlo simulations. (c) 2007 Optical Society of America
引用
收藏
页码:4787 / 4794
页数:8
相关论文
共 30 条
[1]   Bifocal-optical coherenc refractometry of turbid media [J].
Alexandrov, SA ;
Zvyagin, AV ;
Silva, KKMBD ;
Sampson, DD .
OPTICS LETTERS, 2003, 28 (02) :117-119
[2]  
BARER R, 1954, Q J MICROSC SCI, V95, P399
[3]   The spatial variation of the refractive index in biological cells [J].
Beuthan, J ;
Minet, O ;
Helfmann, J ;
Herrig, M ;
Muller, G .
PHYSICS IN MEDICINE AND BIOLOGY, 1996, 41 (03) :369-382
[4]   Effects of refractive index on near-infrared tomography of the breast [J].
Dehghani, H ;
Brooksby, BA ;
Pogue, BW ;
Paulsen, KD .
APPLIED OPTICS, 2005, 44 (10) :1870-1878
[5]   The effects of internal refractive index variation in near-infrared optical tomography: a finite element modelling approach [J].
Dehghani, H ;
Brooksby, B ;
Vishwanath, K ;
Pogue, BW ;
Paulsen, KD .
PHYSICS IN MEDICINE AND BIOLOGY, 2003, 48 (16) :2713-2727
[6]   Determination of refractive indices of porcine skin tissues and Intralipid at eight wavelengths between 325 and 1557 nm [J].
Ding, HF ;
Lu, JQ ;
Jacobs, KM ;
Hu, XH .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 2005, 22 (06) :1151-1157
[7]   Three-dimensional computation of light scattering from cells [J].
Dunn, A ;
RichardsKortum, R .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 1996, 2 (04) :898-905
[8]   The radiative transfer equation for scattering media with a spatially varying refractive index [J].
Ferwerda, HA .
JOURNAL OF OPTICS A-PURE AND APPLIED OPTICS, 1999, 1 (03) :L1-L2
[9]   OPTICAL-CONSTANTS OF WATER IN 200-NM TO 200-MUM WAVELENGTH REGION [J].
HALE, GM ;
QUERRY, MR .
APPLIED OPTICS, 1973, 12 (03) :555-563
[10]   COMPARISON OF REFLECTION METHODS FOR MEASURING OPTICAL CONSTANTS WITHOUT POLARIMETRIC ANALYSIS, AND PROPOSAL FOR NEW METHODS BASED ON BREWSTER ANGLE [J].
HUMPHREYS, S .
PROCEEDINGS OF THE PHYSICAL SOCIETY OF LONDON, 1961, 77 (497) :949-&