TiCl3 catalyzed one-pot protocol for the conversion of aldehydes into 5-substituted 1H-tetrazole

被引：11

作者：

Chakraborty, Rakesh Ranjan ^{[1
]}

Ghosh, Pranab ^{[1
]}

机构：

[1] Univ North Bengal, Dept Chem, Siliguri, W Bengal, India

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 40期

关键词：

Aldehyde; Hydroxylamine hydrochloride; 5-Substituted-1H-tetrazole; Sodium azide; TiCl3; Cycloaddition reaction; SODIUM-AZIDE; NITRILES; DERIVATIVES; IRON; CYCLOADDITION; TETRAZOLES; CHEMISTRY; OXIDATION; ALCOHOLS; AGENTS;

D O I：

10.1016/j.tetlet.2018.08.050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient protocol has been explored for the one-pot synthesis of tetrazole derivatives with wide functional group compatibility in moderate to very high yields starting from aliphatic and aromatic substituted aldehydes. The reaction proceeds via non-isolated oxime and nitrile intermediates. The structures of the products were confirmed by IR and NMR spectroscopy. A plausible reaction mechanism is also provided. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：3616 / 3619

页数：4

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