Tetralone Derivatives From a Deep-Sea-Derived Fungus Cladosporium Sp. HDN17-58

被引：4
作者：
Fan, Cheng [1 ]
Zhou, Guoliang [1 ]
Wang, Wenxue [1 ]
Zhang, Guojian [1 ,2 ]
Zhu, Tianjiao [1 ,2 ]
Che, Qian [1 ,2 ]
Li, Dehai [1 ,2 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China
[2] Qingdao Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2021年 / 16卷 / 04期
关键词：
tetralone derivative; marine-derived fungus; Cladosporium sp; bioactivity; deep sea; METABOLITES;
D O I：
10.1177/1934578X211008322
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One new tetralone derivative, named aladothalen (1), and one known biogenetically related compound, (3S,4S)-3,4,8-trihydroxy-3,4-dihydronaphthalen-1(2 hours)-one (2), were isolated from a deep-sea-derived-fungal Cladosporium sp. HDN17-58. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compound 1 exhibited potent bacteriostatic activity against Bacillus cereus, Mycobacterium phlei and methicillin-resistant coagulase-negative Staphylococci, with a MIC value of 25 mu M.
引用
收藏
页数：4
相关论文
共 14 条
  • [1] Determination of minimum inhibitory concentrations
    Andrews, JM
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 : 5 - 16
  • [2] ISOLATION AND STRUCTURE ELUCIDATION OF HYMATOXIN-B-E AND OTHER PHYTOTOXINS FROM HYPOXYLON-MAMMATUM FUNGAL PATHOGEN OF LEUCE POPLARS
    BORGSCHULTE, K
    REBUFFAT, S
    TROWITZSCHKIENAST, W
    SCHOMBURG, D
    PINON, J
    BODO, B
    [J]. TETRAHEDRON, 1991, 47 (39) : 8351 - 8360
  • [3] Bruhn T., 2011, SPECDIS VERSION 1 53
  • [4] Emmanuel C, 2010, HELV CHIM ACTA, V92, P903, DOI [10.1002/hlca.200800380, DOI 10.1002/HLCA.200800380]
  • [5] Antibiotics for Emerging Pathogens
    Fischbach, Michael A.
    Walsh, Christopher T.
    [J]. SCIENCE, 2009, 325 (5944) : 1089 - 1093
  • [6] Penicyclones A-E, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp F23-2
    Guo, Wenqiang
    Zhang, Zhenzhen
    Zhu, Tianjiao
    Gu, Qianqun
    Li, Dehai
    [J]. JOURNAL OF NATURAL PRODUCTS, 2015, 78 (11): : 2699 - 2703
  • [7] Potential of marine natural products against drug-resistant bacterial infections
    Liu, Miaomiao
    El-Hossary, Ebaa M.
    Oelschlaeger, Tobias A.
    Donia, Mohamed S.
    Quinn, Ronald J.
    Abdelmohsen, Usama Ramadan
    [J]. LANCET INFECTIOUS DISEASES, 2019, 19 (07) : E237 - E245
  • [8] Qu Peng, 2012, Weishengwu Xuebao, V52, P1103
  • [9] SANKAWA U, 1977, TETRAHEDRON LETT, P483
  • [10] Singh SB, 2011, EXPERT REV ANTI-INFE, V9, P589, DOI [10.1586/ERI.11.81, 10.1586/eri.11.81]
12