Microwave-assisted efficient synthesis of dihydropyrimidines in solvent-free condition

被引：37
|
作者：
Mirza-Aghayan, M [1 ]
Bolourtchian, M [1 ]
Hosseini, M [1 ]
机构：
[1] CCERCI, Tehran, Iran
来源：
SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 18期
关键词：
microwave irradiation; Biginelli compounds; solvent-free condition; ferric chloride hexahydrate;
D O I：
10.1081/SCC-200030577
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of 3,4-dihydropyrimidinones from an aldehyde, a ketoester, and a urea or thiourea using a catalytic amount of ferric chloride hexahydrate is described. Microwave irradiation has been used to accelerate the synthesis of the Biginelli compounds under solvent-free conditions and in a short reaction time and with good yield.
引用
收藏
页码：3335 / 3341
页数：7
相关论文
共 50 条
  • [41] An efficient, solvent-free microwave-assisted synthesis and antimicrobial screening of 1,6-dihydropyrimidine analogues
    Desai, N. C.
    Pandya, D. D.
    Satodiya, H. M.
    Rajpara, K. M.
    Joshi, V. V.
    Vaghani, H. V.
    MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (12) : 4412 - 4421
  • [42] EFFICIENT SYNTHESIS OF SULFONAMIDE DERIVATIVES ON SOLID SUPPORTS CATALYZED USING SOLVENT-FREE AND MICROWAVE-ASSISTED METHODS
    Camargo-Ordonez, Argelia
    Moreno-Reyes, Christian
    Olazaran-Santibanez, Fabian
    Martinez-Hernandez, Sheila
    Bocanegra-Garcia, Virgilio
    Rivera, Gildardo
    QUIMICA NOVA, 2011, 34 (05): : 787 - 791
  • [43] Solvent-free microwave-assisted efficient synthesis of 4,4-disubstituted 2-oxazolines
    García-Tellado, F
    Loupy, A
    Petit, A
    Marrero-Terrero, AL
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (22) : 4387 - 4391
  • [44] Microwave-assisted efficient synthesis of azlactone derivatives using TsCl/DMF under solvent-free conditions
    Moghanian, Hassan
    Shabanian, Meisam
    Jafari, Hadi
    COMPTES RENDUS CHIMIE, 2012, 15 (04) : 346 - 349
  • [45] An efficient, solvent-free microwave-assisted synthesis and antimicrobial screening of 1,6-dihydropyrimidine analogues
    N. C. Desai
    D. D. Pandya
    H. M. Satodiya
    K. M. Rajpara
    V. V. Joshi
    H. V. Vaghani
    Medicinal Chemistry Research, 2012, 21 : 4412 - 4421
  • [46] A rapid and efficient solvent-free microwave-assisted synthesis of pyrazolone derivatives containing substituted isoxazole ring
    Zhang, Dawei
    Zhang, Yumin
    Zhao, Tianqi
    Li, Jing
    Hou, Yaya
    Gu, Qiang
    TETRAHEDRON, 2016, 72 (22) : 2979 - 2987
  • [47] Microwave-Assisted Clean Synthesis of Amides via Aza-Wittig Reaction under Solvent-Free Condition
    Sathishkumar, Murugan
    Nagarajan, Sangaraiah
    Velan, Poovan Shanmuga
    Dinesh, Murugan
    Ponnuswamy, Alagusundaram
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2011, 22 (11) : 2065 - 2069
  • [48] Solvent-free, microwave-assisted synthesis of thiophene oligomers via Suzuki coupling
    Melucci, M
    Barbarella, G
    Sotgiu, G
    JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (25): : 8877 - 8884
  • [49] Microwave-Assisted Solvent-Free or Aqueous-Based Synthesis of Biodegradable Polymers
    Balint Koroskenyi
    Stephen P. McCarthy
    Journal of Polymers and the Environment, 2002, 10 : 93 - 104
  • [50] Microwave-assisted solvent-free synthesis of some styryl dyes with benzimidazole nucleus
    Wang, LY
    Zhang, XG
    Li, FM
    Zhang, ZX
    SYNTHETIC COMMUNICATIONS, 2004, 34 (12) : 2245 - 2252
12345