Microwave-assisted efficient synthesis of dihydropyrimidines in solvent-free condition

被引:37
|
作者
Mirza-Aghayan, M [1 ]
Bolourtchian, M [1 ]
Hosseini, M [1 ]
机构
[1] CCERCI, Tehran, Iran
关键词
microwave irradiation; Biginelli compounds; solvent-free condition; ferric chloride hexahydrate;
D O I
10.1081/SCC-200030577
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient synthesis of 3,4-dihydropyrimidinones from an aldehyde, a ketoester, and a urea or thiourea using a catalytic amount of ferric chloride hexahydrate is described. Microwave irradiation has been used to accelerate the synthesis of the Biginelli compounds under solvent-free conditions and in a short reaction time and with good yield.
引用
收藏
页码:3335 / 3341
页数:7
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