Spectroscopic Imaging (1H-2D-CSl) of the prostate:: sequence optimization and correlation with histophatological results.

Purpose: Methodological optimization of a H-1 MR spectroscopic imaging sequence (H-1-2D-CSI) and evaluation of its potential to diagnose prostate cancer as validated by histopathological maps, Methods: The prostates of 18 patients were evaluated by H-1-MR-CSI (voxel dimension: 1 cm(3)) at 1,5 Tesla, This sequence was additionally combined with a frequency selective fat suppression. Results: it was possible to distinguish prostate carcinoma from prostate hyperplasia spectroscopically by the ratio of citrate/(choline + creatine). Differentiation of high-grade prostatic intraepithelial neoplasia (PIN, high-grade) from prostate carcinoma was not unambiguously possible. Prediction of tumor differentiation was not possible by the ratio of citrate/(choline + creatine) by our maximum spatial resolution of 1 cm(3). Conclusion: H-1-2D-CSI is suitable for tumor detection. Tumor differentiation was not possible with the spatial resolution used.