Synthesis and antibacterial activity of new 4-substituted-5-[(2-benzoxazolylthio)methyl]-3-mercapto-4H-1,2,4-triazoles

被引：0
|
作者：
Suresh, K. [1 ]
Sammaiah, G. [1 ]
Vijaya, K. [1 ]
Sarangapani, M. [1 ]
机构：
[1] Kakatiya Univ, Coll Pharmaceut Sci, Med Chem Lab, Warangal 506009, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 16卷 / 03期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New 4-substituted-5-[(2-benzoxazolylthio) methyl]-3-mercapto-4H-1,2,4-triazoles (VI) were prepared from potassium dithiocarbazates (V) by refluxing with various hydrazine derivatives viz., hydrazine hydrate, INH, 2,4-DNP, thiosemicarbazide, semicarbazide and benzoic acid hydrazide. The dithiocarbazates (V) were prepared by reaction of (2-benzoxazolylthio) acetic acid hydrazides (IV) with carbon disulphide in presence of alcoholic potassium hydroxide. The title compounds were characterized by the spectral data and evaluated for antibacterial activity against test organisms by cup plate method. The compounds with 2,4-dinitrophenylanilino and thiourea groups were more active against the test organisms.
引用
收藏
页码：279 / 282
页数：4
相关论文
共 50 条
  • [31] Synthesis and antitumor activity of 3,4,5-substituted 1,2,4-triazoles
    T. R. Ovsepyan
    R. G. Melik-Ogandzhanyan
    G. A. Panosyan
    F. G. Arsenyan
    B. T. Garibdzhanyan
    Pharmaceutical Chemistry Journal, 2009, 43 : 645 - 648
  • [32] Quantitative structure activity relationships for the nematicidal activity of 4-amino-5-substituted aryl-3-mercapto-(4H)-1,2,4-triazoles
    Lakshman, Bijul A.
    Gupta, R. I.
    Prasad, D.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2010, 49 (12): : 1657 - 1661
  • [33] A coupling reaction of 4-amino-5-mercapto-3-substituted-1,2,4-triazoles to generate symmetrically substituted hydrazines
    Li, M
    Zhao, GL
    Wen, LR
    Wang, X
    Zou, XM
    Yang, HZ
    MONATSHEFTE FUR CHEMIE, 2005, 136 (12): : 2045 - 2049
  • [34] Synthesis of new substituted 3-mercapto-1,2,4-triazoles possessing 5-H-dibenzo[a,d]cycloheptene moieties
    Saramet, I
    Banciu, A
    Socea, L
    Draghici, C
    Banciu, MD
    HETEROCYCLIC COMMUNICATIONS, 2003, 9 (06) : 653 - 658
  • [35] Bleaching activity of 4-phenyl-3-(substituted benzylthio)-4H-1,2,4-triazoles
    Yamada, N
    Kusano, D
    Kuwano, E
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2002, 66 (08) : 1671 - 1676
  • [36] Synthesis and Biological Evaluation of 5-Pyridine-4-(arylidine amino)-3-mercapto-4(H)-1,2,4-triazoles
    Bhanojirao, M. E.
    Rajurkar, Vikas G.
    ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (06) : 4733 - 4736
  • [37] Synthesis and biological activity of 3-(3'-bromo-4'-methoxyphenyl)-4-(N-substituted phenylcarboxamido)-5-mercapto-1,2,4-triazoles
    Havaldar, FH
    Mishra, SKJ
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2003, 13 (02) : 167 - 168
  • [38] SYNTHESIS AND CHARACTERIZATION OF SOME 4,5-DISUBSTITUTED-3-MERCAPTO-1,2,4-TRIAZOLES
    SARAMET, I
    BANCIU, MD
    DRAGHICI, C
    REVUE ROUMAINE DE CHIMIE, 1991, 36 (1-3) : 127 - 134
  • [39] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NI(II), CO(II), ZN(II) AND CD(II) COMPLEXES OF 4-SUBSTITUTED-3-MERCAPTO-5-PHENYL-4H-1,2,4-TRIAZOLES
    MUHIELDEEN, Z
    ALOBAIDI, K
    NADIR, M
    ROCHE, VF
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (02) : 101 - 106
  • [40] FRAGMENTATION UNDER ELECTRON-IMPACT OF 4,5-DIAMINO-1,2,4-TRIAZOLES AND 4-AMINO-5-MERCAPTO-1,2,4-TRIAZOLES
    AOUIAL, M
    BERNARDINI, A
    VIALLEFONT, P
    ORGANIC MASS SPECTROMETRY, 1977, 12 (10): : 638 - 643
12345