Synthesis and antibacterial activity of new 4-substituted-5-[(2-benzoxazolylthio)methyl]-3-mercapto-4H-1,2,4-triazoles

被引：0

作者：

Suresh, K. ^{[1
]}

Sammaiah, G. ^{[1
]}

Vijaya, K. ^{[1
]}

Sarangapani, M. ^{[1
]}

机构：

[1] Kakatiya Univ, Coll Pharmaceut Sci, Med Chem Lab, Warangal 506009, Andhra Pradesh, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 16卷 / 03期

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D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New 4-substituted-5-[(2-benzoxazolylthio) methyl]-3-mercapto-4H-1,2,4-triazoles (VI) were prepared from potassium dithiocarbazates (V) by refluxing with various hydrazine derivatives viz., hydrazine hydrate, INH, 2,4-DNP, thiosemicarbazide, semicarbazide and benzoic acid hydrazide. The dithiocarbazates (V) were prepared by reaction of (2-benzoxazolylthio) acetic acid hydrazides (IV) with carbon disulphide in presence of alcoholic potassium hydroxide. The title compounds were characterized by the spectral data and evaluated for antibacterial activity against test organisms by cup plate method. The compounds with 2,4-dinitrophenylanilino and thiourea groups were more active against the test organisms.

引用

页码：279 / 282

页数：4