Voltage-Gated Proton Channels Find Their Dream Job Managing the Respiratory Burst in Phagocytes

被引：78
作者：
DeCoursey, Thomas E. [1 ]
机构：
[1] Rush Univ, Med Ctr, Dept Mol Biophys & Physiol, Chicago, IL 60612 USA
来源：
PHYSIOLOGY | 2010年 / 25卷 / 01期
基金：
美国国家科学基金会;
关键词：
HYDROGEN-ION CURRENTS; INFLUENZA-A VIRUS; ALVEOLAR EPITHELIAL-CELLS; OXIDASE-RELATED PROTON; MEMBRANE-POTENTIAL CHANGES; PHORBOL-MYRISTATE ACETATE; NADPH-OXIDASE; HUMAN-NEUTROPHILS; INTRACELLULAR PH; H+ CHANNEL;
D O I：
10.1152/physiol.00039.2009
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1-S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the production of reactive oxygen species by NADPH oxidase.
引用
收藏
页码：27 / 40
页数：14
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