Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring

被引：40

作者：

Castro, A ^{[1
]}

del Corral, JMM

Gordaliza, M

Grande, C

Gómez-Zurita, A

García-Grávalos, D

San Feliciano, A

机构：

[1] Univ Salamanca, Fac Farm, Dept Quim Farmaceut, E-37007 Salamanca, Spain

[2] Biomar SA, Madrid 28760, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 01期

关键词：

podophyllotoxin; cyclolignans; A-ring modifications; cytotoxicity;

D O I：

10.1016/S0223-5234(02)00007-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT29 and MEL-28). Most. of them maintained their cytotoxicity at the PM level. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：65 / 74

页数：10

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