Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring

被引：40
作者：
Castro, A [1 ]
del Corral, JMM
Gordaliza, M
Grande, C
Gómez-Zurita, A
García-Grávalos, D
San Feliciano, A
机构：
[1] Univ Salamanca, Fac Farm, Dept Quim Farmaceut, E-37007 Salamanca, Spain
[2] Biomar SA, Madrid 28760, Spain
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 01期
关键词：
podophyllotoxin; cyclolignans; A-ring modifications; cytotoxicity;
D O I：
10.1016/S0223-5234(02)00007-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT29 and MEL-28). Most. of them maintained their cytotoxicity at the PM level. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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页码：65 / 74
页数：10
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