RIFM fragrance ingredient safety assessment, 2-thiophenecarboxylic acid, ethyl ester, CAS Registry Number 2810-04-0

被引：0

作者：

Api, A. M. ^{[1
]}

Belsito, D. ^{[2
]}

Biserta, S. ^{[1
]}

Botelho, D. ^{[1
]}

Bruze, M. ^{[3
]}

Burton, G. A., Jr. ^{[4
]}

Buschmann, J. ^{[5
]}

Cancellieri, M. A. ^{[1
]}

Dagli, M. L. ^{[6
]}

Date, M. ^{[1
]}

Dekant, W. ^{[7
]}

Deodhar, C. ^{[1
]}

Fryer, A. D. ^{[8
]}

Gadhia, S. ^{[1
]}

Jones, L. ^{[1
]}

Joshi, K. ^{[1
]}

Kumar, M. ^{[1
]}

Lapczynski, A. ^{[1
]}

Lavelle, M. ^{[1
]}

Lee, I ^{[1
]}

Liebler, D. C. ^{[9
]}

Moustakas, H. ^{[1
]}

Na, M. ^{[1
]}

Penning, T. M. ^{[10
]}

Ritacco, G. ^{[1
]}

Romine, J. ^{[1
]}

Sadekar, N. ^{[1
]}

Schultz, T. W. ^{[11
]}

Selechnik, D. ^{[1
]}

Siddiqi, F. ^{[1
]}

Sipes, I. G. ^{[12
]}

Sullivan, G. ^{[1
]}

Thakkar, Y. ^{[1
]}

Tokura, Y. ^{[13
]}

机构：

[1] Res Inst Fragrance Mat Inc, 50 Tice Blvd, Woodcliff Lake, NJ 07677 USA

[2] Columbia Univ, Dept Dermatol, Med Ctr, 161 Ft Washington Ave, New York, NY 10032 USA

[3] Malmo Univ Hosp, Dept Occupat & Environm Dermatol, Sodra Forstadsgatan 101,Entrance 47, SE-20502 Malmo, Sweden

[4] Univ Michigan, Sch Nat Resources & Environm, Dana Bldg G110,440 Church St, Ann Arbor, MI 48109 USA

[5] Fraunhofer Inst Toxicol & Expt Med, Nikolai Fuchs Str 1, D-30625 Hannover, Germany

[6] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Av Prof Dr Orlando Marques de Paiva 87, BR-05508900 Sao Paulo, Brazil

[7] Univ Wurzburg, Dept Toxicol, Versbacher Str 9, D-97078 Wurzburg, Germany

[8] Oregon Hlth & Sci Univ, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[9] Vanderbilt Univ, Ctr Mol Toxicol, Dept Biochem, Sch Med, 638 Robinson Res Bldg,2200 Pierce Ave, Nashville, TN 37232 USA

[10] Univ Penn, Ctr Excellence Environm Toxicol, Perelman Sch Med, 1316 Biomed Res Bldg BRB 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA

[11] Univ Tennessee, Coll Vet Med, Dept Comparat Med, 2407 River Dr, Knoxville, TN 37996 USA

[12] Univ Arizona, Coll Med, Dept Pharmacol, 1501 North Campbell Ave,POB 245050, Tucson, AZ 85724 USA

[13] Hamamatsu Univ Sch Med, Dept Dermatol, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2021年 / 149卷

关键词：

Genotoxicity; Repeated Dose; Developmental and Reproductive Toxicity; Skin Sensitization; Phototoxicity/Photoallergenicity; Local Respiratory Toxicity; Environmental Safety; DERMAL SENSITIZATION THRESHOLD; PERSONAL CARE; DST APPROACH; CONSUMER EXPOSURE; COSMETICS; CHEMICALS; DATASET; MODEL; TTC;

D O I：

10.1016/j.fct.2020.111863

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The existing information supports the use of this material as described in this safety assessment. 2-Thiophenecarboxylic acid, ethyl ester was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-thiophenecarboxylic acid, ethyl ester is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 2-thiophenecarboxylic acid, ethyl ester is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for non-reactive materials (900 mu g/cm(2)); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; 2-thiophenecarboxylic acid, ethyl ester is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 2-thiophenecarboxylic acid, ethyl ester was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

引用

页数：6

共 50 条

[1] RIFM fragrance ingredient safety assessment, lavandulyl acetate, CAS Registry Number 25905-14-0
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Kumar, M.
Lapczynski, A.
Lavelle, M.
Lee, I
Liebler, D. C.
Moustakas, H.
Na, M.
Penning, T. M.
Ritacco, G.
Romine, J.
Sadekar, N.
Schultz, T. W.
Selechnik, D.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
FOOD AND CHEMICAL TOXICOLOGY, 2021, 153
[2] RIFM fragrance ingredient safety assessment, isobutyraldehyde, CAS Registry Number 78-84-2
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Kumar, M.
Lapczynski, A.
Lavelle, M.
Lee, I
Liebler, D. C.
Moustakas, H.
Na, M.
Penning, T. M.
Ritacco, G.
Romine, J.
Sadekar, N.
Schultz, T. W.
Selechnik, D.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
FOOD AND CHEMICAL TOXICOLOGY, 2021, 149
[3] RIFM fragrance ingredient safety assessment, 2-ethylfuran, CAS Registry Number 3208-16-0
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Kumar, M.
Lapczynski, A.
Lavelle, M.
Lee, I
Liebler, D. C.
Moustakas, H.
Na, M.
Penning, T. M.
Ritacco, G.
Romine, J.
Sadekar, N.
Schultz, T. W.
Selechnik, D.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
FOOD AND CHEMICAL TOXICOLOGY, 2021, 153
[4] RIFM fragrance ingredient safety assessment, sec-butyl ethyl ether, CAS Registry Number 2679-87-0
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Kumar, M.
Lapczynski, A.
Lavelle, M.
Lee, I
Liebler, D. C.
Moustakas, H.
Na, M.
Penning, T. M.
Ritacco, G.
Romine, J.
Sadekar, N.
Schultz, T. W.
Selechnik, D.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
FOOD AND CHEMICAL TOXICOLOGY, 2021, 153
[5] RIFM fragrance ingredient safety assessment, dimethyl disulfide, CAS Registry Number 624-92-0
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Kumar, M.
Lapczynski, A.
Lavelle, M.
Lee, I
Liebler, D. C.
Moustakas, H.
Na, M.
Penning, T. M.
Ritacco, G.
Romine, J.
Sadekar, N.
Schultz, T. W.
Selechnik, D.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
FOOD AND CHEMICAL TOXICOLOGY, 2021, 149
[6] RIFM fragrance ingredient safety assessment, nonane, CAS Registry Number 111-84-2
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Lapczynski, A.
Lavelle, M.
Liebler, D. C.
Na, M.
O'Brien, D.
Patel, A.
Penning, T. M.
Ritacco, G.
Rodriguez-Ropero, F.
Romine, J.
Sadekar, N.
Salvito, D.
Schultz, T. W.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
Tsang, S.
FOOD AND CHEMICAL TOXICOLOGY, 2020, 144
[7] RIFM fragrance ingredient safety assessment, ethyl 2-methyl-4-pentenoate, CAS Registry Number 53399-81-8
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Kumar, M.
Lapczynski, A.
Lavelle, M.
Lee, I
Liebler, D. C.
Moustakas, H.
Na, M.
Penning, T. M.
Ritacco, G.
Romine, J.
Sadekar, N.
Schultz, T. W.
Selechnik, D.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
FOOD AND CHEMICAL TOXICOLOGY, 2021, 153
[8] RIFM fragrance ingredient safety assessment, undecane, CAS Registry Number 1120-21-4
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Kumar, M.
Lapczynski, A.
Lavelle, M.
Lee, I
Liebler, D. C.
Moustakas, H.
Na, M.
Penning, T. M.
Ritacco, G.
Romine, J.
Sadekar, N.
Schultz, T. W.
Selechnik, D.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
Tsang, S.
FOOD AND CHEMICAL TOXICOLOGY, 2020, 146
[9] RIFM fragrance ingredient safety assessment, 2-(3-phenylpropyl) tetrahydrofuran, CAS Registry Number 3208-40-0
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Kumar, M.
Lapczynski, A.
Lavelle, M.
Lee, I
Liebler, D. C.
Moustakas, H.
Na, M.
Penning, T. M.
Ritacco, G.
Romine, J.
Sadekar, N.
Schultz, T. W.
Selechnik, D.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
FOOD AND CHEMICAL TOXICOLOGY, 2021, 149
[10] RIFM fragrance ingredient safety assessment, 2-prenylcyclopentanone, CAS Registry Number 2520-60-7
Api, A. M.
Belsito, D.
Biserta, S.
Botelho, D.
Bruze, M.
Burton, G. A., Jr.
Buschmann, J.
Cancellieri, M. A.
Dagli, M. L.
Date, M.
Dekant, W.
Deodhar, C.
Fryer, A. D.
Gadhia, S.
Jones, L.
Joshi, K.
Kumar, M.
Lapczynski, A.
Lavelle, M.
Lee, I
Liebler, D. C.
Moustakas, H.
Na, M.
Penning, T. M.
Ritacco, G.
Romine, J.
Sadekar, N.
Schultz, T. W.
Selechnik, D.
Siddiqi, F.
Sipes, I. G.
Sullivan, G.
Thakkar, Y.
Tokura, Y.
FOOD AND CHEMICAL TOXICOLOGY, 2021, 149

← 1 2 3 4 5 →