Synthesis of sulfated pectins and their anticoagulant activity

被引：27

作者：

Vityazev, F. V. ^{[1
]}

Golovchenko, V. V. ^{[1
]}

Patova, O. A. ^{[1
]}

Drozd, N. N. ^{[2
]}

Makarov, V. A. ^{[2
]}

Shashkov, A. S. ^{[3
]}

Ovodov, Yu. S. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Physiol, Ural Branch, Komi Sci Ctr, Syktyvkar 167982, Russia

[2] Russian Acad Med Sci, Hematol Sci Ctr, Moscow 125167, Russia

[3] Russian Acad Sci, Zelinsky Inst Organ Chem, Moscow 117913, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2010年 / 75卷 / 06期

关键词：

lemnan; bergenan; sulfated pectin; sulfated galacturonan; anticoagulant activity; Bergenia crassifolia L; Lemna minor L; HEPARIN ASSAY; POLYSACCHARIDE; PLASMA;

D O I：

10.1134/S0006297910060118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The following pectins were sulfated: bergenan BC (the pectin of Bergenia crassifolia L), lemnan LM (the pectin of Lemna minor L), and galacturonan as a backbone of pectins. Pyridine monomethyl sulfate, pyridine sulfotrioxide, and chlorosulfonic acid were used as reagents for sulfation. Chlorosulfonic acid proved to be the optimal reagent for sulfation of galacturonan and other pectins. Galacturonan and pectin derivatives with different degrees of sulfation were synthesized and their anticoagulant activities were shown to depend on the quantity of sulfate groups in the pectin macromolecules.

引用

页码：759 / 768

页数：10

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