Stimulation of Innate and Adaptive Immune Cells with Graphene Oxide and Reduced Graphene Oxide Affect Cancer Progression

被引：13

作者：

Yunus, Muhammad Amir ^{[1
]}

Ramli, Muhammad Mahyiddin ^{[2
,3
]}

Osman, Nurul Huda ^{[4
]}

Mohamed, Rafeezul ^{[5
]}

机构：

[1] Univ Sains Malaysia, Infect Cluster, Adv Med & Dent Inst, Kepala Batas 13200, Pulau Pinang, Malaysia

[2] Univ Malaysia Perlis, Ctr Excellence CEGeoGTech, Geopolymer & Green Technol, Arau, Perlis, Malaysia

[3] Univ Malaysia Perlis, Fac Elect Engn Technol, Arau, Perlis, Malaysia

[4] Univ Putra Malaysia, Fac Sci, Dept Phys, Appl Electmagnet Lab 1, Serdang 43400, Selangor, Malaysia

[5] Univ Sains Malaysia, Regenerat Med Cluster, Adv Med & Dent Inst, Kepala Batas 13200, Pulau Pinang, Malaysia

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2021年 / 69卷 / 01期

关键词：

Graphene oxide; Reduced graphene oxide; Innate immune cells; Adaptive immune cells; Cancers; TUMOR MICROENVIRONMENT; DENDRITIC CELLS; SURFACE OXIDATION; IN-VITRO; MACROPHAGES; NEUTROPHIL; ACTIVATION; RESPONSES; HEMOCOMPATIBILITY; IMMUNOTOXICITY;

D O I：

10.1007/s00005-021-00625-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sole nanomaterials or nanomaterials bound to specific biomolecules have been proposed to regulate the immune system. These materials have now emerged as new tools for eliciting immune-based therapies to treat various cancers. Graphene, graphene oxide (GO) and reduced GO (rGO) are the latest nanomaterials among other carbon nanotubes that have attracted wide interest among medical industry players due to their extraordinary properties, inert-state, non-toxic and stable dispersion in a various solvent. Currently, GO and rGO are utilized in various biomedical application including cancer immunotherapy. This review will highlight studies that have been carried out in elucidating the stimulation of GO and rGO on selected innate and adaptive immune cells and their effect on cancer progression to shed some insights for researchers in the development of various GO- and rGO-based immune therapies against various cancers.

引用

页数：16

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