Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder

被引：16

作者：

Prigge, Molly B. D. ^{[1
,2
,3
,13
]}

Bigler, Erin D. ^{[4
,5
]}

Travers, Brittany G. ^{[3
,6
]}

Froehlich, Alyson ^{[7
]}

Abildskov, Tracy ^{[4
,5
]}

Anderson, Jeffrey S. ^{[2
,8
]}

Alexander, Andrew L. ^{[3
,9
]}

Lange, Nicholas ^{[10
,11
]}

Lainhart, Janet E. ^{[3
,9
]}

Zielinski, Brandon A. ^{[1
,12
]}

机构：

[1] Univ Utah, Dept Pediat, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Radiol, Salt Lake City, UT 84132 USA

[3] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA

[4] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA

[5] Brigham Young Univ, Dept Neurosci, Provo, UT 84602 USA

[6] Univ Wisconsin, Occupat Therapy Program Kinesiol, Madison, WI USA

[7] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA

[8] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

[9] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA

[10] Harvard Univ, McLean Hosp, Cambridge, MA 02138 USA

[11] Harvard Univ, Dept Psychiat, Cambridge, MA 02138 USA

[12] Univ Utah, Dept Neurol, Salt Lake City, UT USA

[13] Univ Utah, 417 Wakara Way,Suite 3111, Salt Lake City, UT 84108 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2018年 / 48卷 / 10期

关键词：

Autism spectrum disorder (ASD); Social Responsiveness Scale (SRS); Cortical thickness; Brain development; Longitudinal; Autism severity; COMPARABLE SURFACE-AREA; CHILDREN; AGE; TRAITS; VOLUME; COMMUNICATION; REGIONS; ADOLESCENTS; CHILDHOOD; ANATOMY;

D O I：

10.1007/s10803-018-3566-1

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

The relationship between brain development and clinical heterogeneity in autism (ASD) is unknown. This study examines the Social Responsiveness Scale (SRS) in relation to the longitudinal development of cortical thickness. Participants (N = 91 ASD, N = 56 TDC; 3-39 years at first scan) were scanned up to three times over a 7-year period. Mixed-effects models examined cortical thickness in relation to SRS score. ASD participants with higher SRS scores showed regionally increased age-related cortical thinning. Regional thickness differences and reduced age-related cortical thinning were found in predominantly right lateralized regions in ASD with decreasing SRS scores over time. Our findings emphasize the importance of examining clinical phenotypes in brain-based studies of ASD.

引用

页码：3319 / 3329

页数：11

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