Abnormal steroidogenesis and aromatase activity in preeclampsia

被引：43

作者：

Berkane, Nadia ^{[1
,4
]}

Liere, Philippe ^{[5
,6
]}

Lefevre, Guillaume ^{[2
]}

Alfaidy, Nadia ^{[7
]}

Nahed, Roland Abi ^{[7
]}

Vincent, Jessica ^{[4
]}

Oudinet, Jean-Paul ^{[5
,6
]}

Pianos, Antoine ^{[5
,6
]}

Cambourg, Annie ^{[5
,6
]}

Rozenberg, Patrick ^{[8
]}

Galichon, Pierre ^{[3
]}

Rousseau, Alexandra ^{[9
]}

Simon, Tabassome ^{[9
]}

Schumacher, Michael ^{[5
,6
]}

Chabbert-Buffet, Nathalie ^{[1
]}

Hertig, Alexandre ^{[3
]}

机构：

[1] Sorbonne Univ, AP HP, Dept Gynecol & Obstet & Reprod Med, Paris, France

[2] Sorbonne Univ, AP HP, Dept Biochem & Hormonol, Paris, France

[3] Sorbonne Univ, Tenon Hosp, AP HP, Dept Nephrol, Paris, France

[4] Univ Geneva Hosp HUG, Dept Gynecol & Obstet, Geneva, Switzerland

[5] INSERM, U1195, Le Kremlin Bicetre, France

[6] Univ Paris Sud, Le Kremlin Bicetre, France

[7] INSERM, U1036, Biosci & Biotechnol Inst, Grenoble, France

[8] Poissy St Germain Hosp, Dept Obstet & Gynecol, Poissy, France

[9] St Antoine Hosp, Ctr Est URCEST, Dept Clin Res, Paris, France

来源：

PLACENTA | 2018年 / 69卷

关键词：

Angiogenesis; Aromatase; Estrogen; Preeclampsia; CATECHOL-O-METHYLTRANSFERASE; ENDOTHELIAL GROWTH-FACTOR; MINERALOCORTICOID RECEPTOR; PREDICTING PREECLAMPSIA; HYPERTENSIVE DISORDERS; ANGIOGENIC FACTORS; HUMAN-PREGNANCY; FACTOR RATIO; ESTROGEN; PROGESTERONE;

D O I：

10.1016/j.placenta.2018.07.004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Introduction: Estrogens and progesterone play critical roles in angiogenesis and vasodilation. Moreover, placental aromatase deficiency is detected in women with preeclampsia (PE) at delivery. We hypothesized that abnormal steroidogenesis occurs much earlier than typical PE diagnosis. Thus, we investigated whether the circulating steroid profile was already disturbed at 24-29 weeks of gestation in women with subsequent PE, and compared the profile with that of women with "placental" small gestational age (SGA) without PE. Methods: We selected nulliparous women (n=90) from the MOMA trial, including women with PE (n=25), SGA (n=25), and controls (NP; n=40), for plasma steroid profiling by gas chromatography/mass spectrometry and to measure placental growth factor and soluble fms-like tyrosine kinase-1. Placental aromatase expression was evaluated in a new set of women. Results: Compared with that of controls, the women with PE had a significantly lower estrone/androstenedione ratio, and exhibited a decreasing trend for estradiol and estrone levels. Lower estriol levels were observed in the SGA group compared to the NP group. Compared with that of controls, the women with PE and SGA had significantly higher levels of 20a-dihydroprogesterone (20a-DHP) and 20a-DHP/progesterone ratios. Pregnenolone sulfate levels were lower in the PE group than in the NP and SGA groups. Decreased expression of aromatase was observed in the PE group compared to the control group. Discussion: Preeclampsia appears to be characterized by specific steroidogenesis dysregulation long before PE diagnosis, highlighting potential new biomarkers of PE.

引用

页码：40 / 49

页数：10

共 56 条

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