Intrauterine insemination with gonadotropin stimulation or in vitro fertilization for the treatment of unexplained subfertility: a randomized controlled trial

被引：40

作者：

Nandi, Anupa ^{[1
]}

Bhide, Priya ^{[1
]}

Hooper, Richard ^{[2
]}

Gudi, Anil ^{[1
]}

Shah, Amit ^{[1
]}

Khan, Khalid ^{[2
]}

Homburg, Roy ^{[1
]}

机构：

[1] Homerton Univ Hosp, Fertil Unit, London E9 6SR, England

[2] Blizard Inst, Womens Hlth Res Unit, London, England

来源：

FERTILITY AND STERILITY | 2017年 / 107卷 / 06期

关键词：

In vitro fertilization; intrauterine insemination; unexplained subfertility; unexplained infertility; OVARIAN STIMULATION; COUPLES; PREDICTION; MANAGEMENT; SUCCESS; CYCLES; SINGLE; SEMEN;

D O I：

10.1016/j.fertnstert.2017.03.028

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To evaluate the best first line management option for the treatment of unexplained subfertility-controlled ovarian hyperstimulation (COH) with gonadotropins and IUI or IVF. Design: Randomized controlled trial. Setting: Single center trial in a tertiary referral unit. Patient(s): Couples with unexplained subfertility. Intervention(s): Couples were randomized to receive either three cycles of IUI + COH or one cycle of IVF. Main Outcome Measure(s): Singleton pregnancy rate (PR) per couple. Result(s): A total of 207 couples were randomly assigned to three cycles of IUI + COH (n = 101) or one cycle of IVF (n = 106). There were 25 (24.7%) singleton live births for the IUI + COH group and 33 (31.1%) for the IVF group (relative risk, 1.3; 95% confidence interval [CI] 0.81 - 1.96) with an absolute risk difference of 6.4% (95% CI - 5.8% to 18.6%). The multiple pregnancies per live birth were 4 (13.8%) for the IUI + COH group and 3 (8.3%) for the IVF group (relative risk, 0.6; 95% CI 0.14- 2.4). There were no cases of ovarian hyperstimulation syndrome (OHSS) in the IUI group and three cases of OHSS (3.7%) in the IVF group. There were 17 live births from spontaneous conception in between treatment cycles (8.2%). Conclusion(s): The singleton live birth rate with one cycle of IVF was not significantly different than three cycles of IUI + COH. (C)2017 by American Society for Reproductive Medicine.

引用

页码：1329 / +

页数：9

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