Biodegradable gemini multiblock poly(ε-caprolactone urethane)s toward controllable micellization

被引：49
作者：
Ding, Mingming [1 ]
Zhou, Lijuan [1 ]
Fu, Xiaoting [1 ]
Tan, Hong [1 ]
Li, Jiehua [1 ]
Fu, Qiang [1 ]
机构：
[1] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China
来源：
SOFT MATTER | 2010年 / 6卷 / 09期
基金：
中国国家自然科学基金;
关键词：
AMPHIPHILIC BLOCK-COPOLYMERS; DRUG-RELEASE BEHAVIORS; POLYURETHANE SCAFFOLDS; POLY(ETHYLENE GLYCOL); TRIBLOCK COPOLYMERS; MICELLE FORMATION; DELIVERY SYSTEMS; NANOPARTICLES; DIBLOCK; PROBES;
D O I：
10.1039/b926689e
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Unique self-assembly behavior of novel nontoxic gemini cationic biodegradable multiblock poly(epsilon-caprolactone urethane)s which contain both gemini quaternary ammonium and PEG groups is firstly reported. The micellar size, size distributions, zeta potential, CMC and K-v could be well-tailored for application in drug and gene delivery.
引用
收藏
页码：2087 / 2092
页数：6
相关论文
共 40 条
[1]   Nano-engineering block copolymer aggregates for drug delivery [J].
Allen, C ;
Maysinger, D ;
Eisenberg, A .
COLLOIDS AND SURFACES B-BIOINTERFACES, 1999, 16 (1-4) :3-27
[2]   CRITICAL MICELLIZATION PHENOMENA IN BLOCK POLYELECTROLYTE SOLUTIONS [J].
ASTAFIEVA, I ;
ZHONG, XF ;
EISENBERG, A .
MACROMOLECULES, 1993, 26 (26) :7339-7352
[3]   Polymers get organized [J].
Bucknall, DG ;
Anderson, HL .
SCIENCE, 2003, 302 (5652) :1904-1905
[4]   Synthesis, Degradation, and Cytotoxicity of Multiblock Poly(ε-caprolactone urethane)s Containing Gemini Quaternary Ammonium Cationic Groups [J].
Ding, Mingming ;
Li, Jiehua ;
Fu, Xiaoting ;
Zhou, Jian ;
Tan, Hong ;
Gu, Qun ;
Fu, Qiang .
BIOMACROMOLECULES, 2009, 10 (10) :2857-2865
[5]   Block copolymer micelles: preparation, characterization and application in drug delivery [J].
Gaucher, G ;
Dufresne, MH ;
Sant, VP ;
Kang, N ;
Maysinger, D ;
Leroux, JC .
JOURNAL OF CONTROLLED RELEASE, 2005, 109 (1-3) :169-188
[6]   Preparation, characterization, and drug release behaviors of drug nimodipine-loaded poly(ε-caprolactone)-poly(ethylene oxide)-poly(ε-caprolactone) amphiphilic triblock copolymer micelles [J].
Ge, HX ;
Hu, Y ;
Jiang, XQ ;
Cheng, DM ;
Yuan, YY ;
Bi, H ;
Yang, CZ .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (06) :1463-1473
[7]   Synthesis and 'Schizophrenic' micellization of double hydrophilic AB4 miktoarm star and AB diblock copolymers:: Structure and kinetics of micellization [J].
Ge, Zhishen ;
Cai, Yuanli ;
Yin, Jun ;
Zhu, Zhiyuan ;
Rao, Jingyi ;
Liu, Shiyong .
LANGMUIR, 2007, 23 (03) :1114-1122
[8]   Biodegradable porous polyurethane scaffolds for tissue repair and regeneration [J].
Gorna, Katarzyna ;
Gogolewski, Sylwester .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 79A (01) :128-138
[9]   The use of biodegradable polyurethane scaffolds for cartilage tissue engineering: potential and limitations [J].
Grad, S ;
Kupcsik, L ;
Gorna, K ;
Gogolewski, S ;
Alini, M .
BIOMATERIALS, 2003, 24 (28) :5163-5171
[10]   Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications [J].
Guan, JJ ;
Fujimoto, KL ;
Sacks, MS ;
Wagner, WR .
BIOMATERIALS, 2005, 26 (18) :3961-3971
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