A first approach to a neuropsychological screening tool using eye-tracking for bedside cognitive testing based on the Edinburgh Cognitive and Behavioural ALS Screen

被引：16

作者：

Keller, Juergen ^{[1
]}

Krimly, Amon ^{[1
]}

Bauer, Lisa ^{[1
]}

Schulenburg, Sarah ^{[1
]}

Boehm, Sarah ^{[1
]}

Aho-Oezhan, Helena E. A. ^{[1
]}

Uttner, Ingo ^{[1
]}

Gorges, Martin ^{[1
]}

Kassubek, Jan ^{[1
]}

Pinkhardt, Elmar H. ^{[1
]}

Abrahams, Sharon ^{[2
,3
]}

Ludolph, Albert C. ^{[1
]}

Lule, Dorothee ^{[1
]}

机构：

[1] Univ Ulm, Dept Neurol, Ulm, Germany

[2] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Euan MacDonald Ctr Motor Neuron Dis Res, Human Cognit Neurosci PPLS, Edinburgh, Midlothian, Scotland

[3] Univ Edinburgh, Anne Rowling Regenerat Neurol Clin, Edinburgh, Midlothian, Scotland

来源：

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION | 2017年 / 18卷 / 5-6期

关键词：

Eye-tracking; cognition; Edinburgh Cognitive and Behavioural ALS Screen; amyotrophic lateral sclerosis; motor neuron disease; AMYOTROPHIC-LATERAL-SCLEROSIS; DYSFUNCTION; IMPAIRMENT;

D O I：

10.1080/21678421.2017.1313869

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Reliable assessment of cognitive functions is a challenging task in amyotrophic lateral sclerosis (ALS) patients unable to speak and write. We therefore present an eye-tracking based neuropsychological screening tool based on the Edinburgh Cognitive and Behavioural ALS Screen (ECAS), a standard screening tool for cognitive deficits in ALS. Methods: In total, 46 ALS patients and 50 healthy controls matched for age, gender and education were tested with an oculomotor based and a standard paper-and-pencil version of the ECAS. Results: Significant correlation between both versions was observed for ALS patients and healthy controls in the ECAS total score and in all of its ALS-specific domains (all r>0.3; all p<0.05). The eye-tracking version of the ECAS reliably distinguished between ALS patients and healthy controls in the ECAS total score (p<0.05). Also, cognitively impaired and non-impaired patients could be reliably distinguished with a specificity of 95%. Conclusion: This study provides first evidence that the eye-tracking based ECAS version is a promising approach for assessing cognitive deficits in ALS patients who are unable to speak or write.

引用

页码：443 / 450

页数：8

共 35 条

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