Analysis of choroidal vascularity index in multiple sclerosis patients without optic neuritis attack

Background: To evaluate the choroidal structural changes in multiple sclerosis (MS) patients without previous optic neuritis (ON) attacks.& nbsp;Methods: Forty eyes of 20 MS patients without a history of ON and 40 eyes of 20 age-matched healthy volunteers were included in this study. The choroidal thickness (CT) was measured at three points; subfoveal, 1500 mu m nasal to the fovea, and 1500 mu m temporal to the fovea. Choroidal area (CA), luminal area (LA), and choroidal vascularity index (CVI) were calculated using ImageJ.& nbsp;Results: The mean subfoveal, nasal and temporal CT were decreased in MS patients compared to controls (for all, p < 0.001). The mean LA was 0.572 +/- 0.113 mm(2) in MS group, and 0.729 +/- 0.188 mm(2) in controls (p = 0.002). The mean CVI was decreased in the MS group (69.38% +/- 4.87) in comparison to the controls (73.41% +/- 5.18) (p = 0.034).& nbsp;Conclusion: The current study demonstrated significant anatomical alterations of the choroid in the eyes of patients with MS.