Zwitterionic drug nanocarriers: A biomimetic strategy for drug delivery

被引：134

作者：

Jin, Qiao ^{[1
]}

Chen, Yangjun ^{[1
]}

Wang, Yin ^{[1
]}

Ji, Jian ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionlizat, Minist Agr, Hangzhou 310027, Zhejiang, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 124卷

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

Zwitterion; Drug nanocarrier; Phosphorylcholine; Carboxybetaine; Sulfobetaine; Biomimetic; BLOCK-COPOLYMER MICELLES; GENE DELIVERY; IN-VITRO; POLYMERIC NANOPARTICLES; BIODEGRADABLE POLYMERSOMES; CELLULAR UPTAKE; CANCER; DNA; ENCAPSULATION; STABILITY;

D O I：

10.1016/j.colsurfb.2014.07.013

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Nanomaterials self-assembled from amphiphilic functional copolymers have emerged as safe and efficient nanocarriers for delivery of therapeutics. Surface engineering of the nanocarriers is extremely important for the design of drug delivery systems. Bioinspired zwitterions are considered as novel non-fouling materials to construct biocompatible and bioinert nanocarriers. As an alternative to poly(ethylene glycol) (PEG), zwitterions exhibit some unique properties that PEG do not have. In this review, we highlight recent progress of the design of drug nanocarriers using a zwitterionic strategy. The possible mechanism of stealth properties of zwitterions was proposed. The advantages of zwitterionic drug nanocarriers deriving from phosphorylcholine (PC), carboxybetaine (CB), and sulfobetaine (SB) are also discussed. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：80 / 86

页数：7

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