Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine

被引：13

作者：

Fernandes, Diogo C. ^{[1
,2
]}

Reis, Rui L. ^{[1
,2
]}

Oliveira, J. Miguel ^{[1
,2
]}

机构：

[1] Univ Minho, Headquarters European Inst Excellence Tissue Engn, 3Bs Res Grp, I3Bs Res Inst Biomat Biodegradables & Biomimet, AvePk, P-4805017 Barco Gmr, Portugal

[2] ICVS 3Bs Portuguese Govt Associate Lab, P-4805017 Braga, Portugal

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 03期

关键词：

BLOOD-BRAIN-BARRIER; CEREBRAL ORGANOIDS; ELECTRICAL-RESISTANCE; EXTRACELLULAR-MATRIX; ENDOTHELIAL-CELLS; IMMUNE-SYSTEM; PERMEABILITY; DISEASE; NEURONS; VIRUS;

D O I：

10.1016/j.drudis.2020.11.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Clinical trials continue to fall short regarding drugs to effectively treat brain-affecting diseases. Although there are many causes of these shortcomings, the most relevant are the inability of most therapeutic agents to cross the blood?brain barrier (BBB) and the failure to translate effects from animal models to patients. In this review, we analyze the most recent developments in BBB, neural, and neurovascular models, analyzing their impact on the drug development process by considering their quantitative and phenotypical characterization. We offer a perspective of the state-of-the-art of the models that could revolutionize the pharmaceutical industry. Clinical trials continue to fall short regarding drugs to effectively treat brain-affecting diseases. Although there are many causes of these shortcomings, the most relevant are the inability of most therapeutic agents to cross the blood?brain barrier (BBB) and the failure to translate effects from animal models to patients. In this review, we analyze the most recent developments in BBB, neural, and neurovascular models, analyzing their impact on the drug development process by considering their quantitative and phenotypical characterization. We offer a perspective of the state-of-the-art of the models that could revolutionize the pharmaceutical industry.

引用

页码：754 / 768

页数：15

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