Fluoroquinolone Resistance and Clostridium difficile, Germany

被引:43
作者
Zaiss, Nils Henning [1 ]
Witte, Wolfgang [1 ]
Nuebel, Ulrich [1 ]
机构
[1] Robert Koch Inst, Div Nosocomial Infect, D-38855 Wernigerode, Germany
关键词
MOXIFLOXACIN; INFECTIONS; MUTATIONS; EPIDEMIC;
D O I
10.3201/eid1604.090859
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We characterized 670 Clostridium difficile isolates collected from patients in 84 hospitals in Germany in 2008. PCR ribotyping showed high prevalence of ribotype 001 and restricted dissemination of ribotype 027 strains. Fluoroquinolone resistance and associated gyrase mutations were frequent in various ribotypes, but no resistance to metronidazole or vancomycin was noted.
引用
收藏
页码:675 / 677
页数:3
相关论文
共 15 条
[1]   Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA [J].
Ackermann, G ;
Tang, YJ ;
Kueper, R ;
Heisig, P ;
Rodloff, AC ;
Silva, J ;
Cohen, SH .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (08) :2348-2353
[2]   Development of a new PCR-ribotyping method for Clostridium difficile based on ribosomal RNA gene sequencing [J].
Bidet, P ;
Barbut, F ;
Lalande, V ;
Burghoffer, B ;
Petit, JC .
FEMS MICROBIOLOGY LETTERS, 1999, 175 (02) :261-266
[3]  
BORGMANN S, 2008, EURO SURVEILL, V13
[4]  
Brazier J S, 2008, Euro Surveill, V13
[5]   gyrA and gyrB mutations are implicated in cross-resistance to ciprofloxacin and moxifloxacin in Clostridium difficile [J].
Dridi, L ;
Tankovic, J ;
Burghoffer, B ;
Barbut, F ;
Petit, JC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (11) :3418-3421
[6]  
Hensgens MP, 2009, EUROSURVEILLANCE, V14, P7
[7]   Mechanisms of fluoroquinolone resistance [J].
Hooper, DC .
DRUG RESISTANCE UPDATES, 1999, 2 (01) :38-55
[8]  
Kleinkauf N., 2007, EUROSURVEILLANCE, V12
[9]   Emergence of Clostridium difficile-associated disease in North America and Europe [J].
Kuijper, E. J. ;
Coignard, B. ;
Tull, P. .
CLINICAL MICROBIOLOGY AND INFECTION, 2006, 12 :2-18
[10]   Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain [J].
Labbe, Annie-Claude ;
Poirier, Louise ;
MacCannell, Duncan ;
Louie, Thomas ;
Savoie, Michel ;
Beliveau, Claire ;
Laverdiere, Michel ;
Pepin, Jacques .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (09) :3180-3187