Synapse formation: If it looks like a duck and quacks like a duck ...

被引：27
作者：
Cantallops, I [1 ]
Cline, HT [1 ]
机构：
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
CURRENT BIOLOGY | 2000年 / 10卷 / 17期
关键词：
D O I：
10.1016/S0960-9822(00)00663-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuroligin and neurexin form an intercellular adhesion complex sufficient to trigger formation of functional presynaptic elements in vitro. This single molecular interaction appears to initiate clustering of synaptic vesicles, assembly of vesicle release machinery and morphological changes at the presynaptic membrane.
引用
收藏
页码：R620 / R623
页数：4
相关论文
共 23 条
  • [1] Assembly of presynaptic active zones from cytoplasmic transport packets
    Ahmari, SE
    Buchanan, J
    Smith, SJ
    [J]. NATURE NEUROSCIENCE, 2000, 3 (05) : 445 - 451
  • [2] Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin I beta gene expression followed by late-onset neuromotor deterioration
    Andres, C
    Beeri, R
    Friedman, A
    LevLehman, E
    Henis, S
    Timberg, R
    Shani, M
    Soreq, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) : 8173 - 8178
  • [3] Distribution of neurotransmitter secretion in growing axons
    Antonov, I
    Chang, S
    Zakharenko, S
    Popov, SV
    [J]. NEUROSCIENCE, 1999, 90 (03) : 975 - 984
  • [4] A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain
    Butz, S
    Okamoto, M
    Südhof, TC
    [J]. CELL, 1998, 94 (06) : 773 - 782
  • [5] Developmental regulation of spine motility in the mammalian central nervous system
    Dunaevsky, A
    Tashiro, A
    Majewska, A
    Mason, C
    Yuste, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) : 13438 - 13443
  • [6] Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis
    Grifman, M
    Galyam, N
    Seidman, S
    Soreq, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) : 13935 - 13940
  • [7] A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
    Hirao, K
    Hata, Y
    Ide, N
    Takeuchi, M
    Irie, M
    Yao, I
    Deguchi, M
    Toyoda, A
    Sudhof, TC
    Takai, Y
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (33) : 21105 - 21110
  • [8] Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
    Husi, H
    Ward, MA
    Choudhary, JS
    Blackstock, WP
    Grant, SGN
    [J]. NATURE NEUROSCIENCE, 2000, 3 (07) : 661 - 669
  • [9] NEUROLIGIN-1 - A SPLICE SITE-SPECIFIC LIGAND FOR BETA-NEUREXINS
    ICHTCHENKO, K
    HATA, Y
    NGUYEN, T
    ULLRICH, B
    MISSLER, M
    MOOMAW, C
    SUDHOF, TC
    [J]. CELL, 1995, 81 (03) : 435 - 443
  • [10] Binding of neuroligins to PSD-95
    Irie, M
    Hata, Y
    Takeuchi, M
    Ichtchenko, K
    Toyoda, A
    Hirao, K
    Takai, Y
    Rosahl, TW
    Sudhof, TC
    [J]. SCIENCE, 1997, 277 (5331) : 1511 - 1515
123