MECHANISMS IN ENDOCRINOLOGY Aging and anti-aging: a Combo-Endocrinology overview

被引：61

作者：

Diamanti-Kandarakis, Evanthia ^{[1
]}

Dattilo, Maurizio ^{[2
]}

Macut, Djuro ^{[3
]}

Duntas, Leonidas ^{[4
,5
]}

Gonos, Efstathios S. ^{[6
]}

Goulis, Dimitrios G. ^{[7
]}

Gantenbein, Christina Kanaka ^{[8
]}

Kapetanou, Marianna ^{[6
,11
]}

Koukkou, Eftychia ^{[9
]}

Lambrinoudaki, Irene ^{[10
]}

Michalaki, Marina

Eftekhari-Nader, Shahla ^{[12
]}

Pasquali, Renato ^{[13
]}

Peppa, Melpomeni ^{[14
,15
]}

Tzanela, Marinella ^{[16
]}

Vassilatou, Evangeline ^{[17
]}

Vryonidou, Andromachi ^{[18
]}

机构：

[1] Euroclin Hosp, Dept Endocrinol Diabet & Metab Dis, Athens, Greece

[2] Parthenogen, Lugano, Switzerland

[3] Univ Belgrade, Fac Med, Clin Endocrinol Diabet & Metab Dis, Belgrade, Serbia

[4] Univ Ulm, Med Sch, Ulm, Germany

[5] Univ Athens, Evgenid Hosp, Endocrine Clin, Athens, Greece

[6] Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece

[7] Aristotle Univ Thessaloniki, Unit Reprod Endocrinol, Sch Med, Dept Obstet & Gynecol 1, Thessaloniki, Greece

[8] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Dept Pediat 1, Sch Med, Athens, Greece

[9] Elena Venizelou Hosp, Endocrine Dept, Athens, Greece

[10] Univ Athens, Aretaieio Hosp, Dept Obstet & Gynecol 2, Athens, Greece

[11] Univ Hosp Patras, Dept Internal Med, Endocrine Div, Patras, Greece

[12] Univ Texas Houston, Mc Goven Med Sch, Dept Internal Med, Houston, TX USA

[13] S Orsola Malpighi Hosp Bologna, Bologna, Italy

[14] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Dept Internal Med Propaedeut 2, Res Inst, Athens, Greece

[15] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Ctr Diabet, Athens, Greece

[16] Evangelismos Med Ctr, Athens, Greece

[17] Attikon Univ Hosp, Dept Internal Med 2, Endocrine Unit, Athens, Greece

[18] Red Cross Hosp, Dept Endocrinol Diabet & Metab, Athens, Greece

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2017年 / 176卷 / 06期

关键词：

POLYCYSTIC-OVARY-SYNDROME; POSTMENOPAUSAL HORMONE-THERAPY; LATE-ONSET HYPOGONADISM; AMYOTROPHIC-LATERAL-SCLEROSIS; IMPAIRED GLUCOSE-TOLERANCE; ESTROGEN PLUS PROGESTIN; GLYCATION END-PRODUCTS; BODY-MASS INDEX; SUBCLINICAL HYPOTHYROIDISM; OXIDATIVE STRESS;

D O I：

10.1530/EJE-16-1061

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent, heterogeneous decline of physiological functions, aging is orchestrated by a plethora of molecular mechanisms, which vividly interact to alter body homeostasis. The ability of an organism to adjust to these alterations, in conjunction with the dynamic effect of various environmental stimuli across lifespan, promotes longevity, frailty or disease. Endocrine function undergoes major changes during aging, as well. Specifically, alterations in hormonal networks and concomitant hormonal deficits/excess, augmented by poor sensitivity of tissues to their action, take place. As hypothalamic-pituitary unit is the central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae that can impair the quality of life and promote frailty and disease. Delineating the hormonal signaling alterations that occur across lifespan and exploring possible remedial interventions could possibly help us improve the quality of life of the elderly and promote longevity.

引用

页码：R283 / R308

页数：26

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